Anthony Mato

Tumor Lysis Syndrome (TLS) Also known as: Uric acid nephropathy, spontaneous TLS, acute renal failure 1. Description of the problem Tumor lysis syndrome (TLS) is defined by the metabolic derangements of hyperuricemia, hyperphosphatemia, hyperkalemia, hypocalcemia and acute renal failure that occur in the setting of rapid tumor destruction. When cellular lysis occurs (either spontaneously or…

Leukostasis Synonyms Continue Reading Hyperleukocytosis Leukemic blast crisis Related Conditions Acute myelogenous leukemia Acute lymphoblastic leukemia Chronic myelogenous leukemia Chronic lymphocytic leukemia 1. Description of the problem What every clinician needs to know Patients with both acute (AML, ALL) and chronic leukemias (CML, CLL) frequently present with hyperleukocytosis. This is a laboratory definition to describe…