Aric Parnes

Paroxysmal nocturnal hemoglobinuria I. What every physician needs to know. Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic anemia due to an acquired mutation that results in red blood cells prone to intravascular complement-mediated destruction. Its key features include hemolytic anemia, hemoglobinuria, thromboembolic disease including Budd-Chiari syndrome, and aplastic anemia. II. Diagnostic Confirmation: Are you sure…

Basophilia I. Problem/Condition. Basophilia is defined as an elevated absolute basophil count greater than 200 cells/uL or relative basophil count greater than 2%, though each laboratory should set their own normal ranges based on the local population. The elevation of these cells can often suggest underlying diseases, such as myeloproliferative disease or chronic inflammation. This…