Paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria I. What every physician needs to know. Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic anemia due to an acquired mutation that results in red blood cells prone to intravascular complement-mediated destruction. Its key features include hemolytic anemia, hemoglobinuria, thromboembolic disease including Budd-Chiari syndrome, and aplastic anemia. II. Diagnostic Confirmation: Are you sure…