Brian Doyle

All articles by Brian Doyle


I. Problem/Condition. A monocyte is a type of leukocyte produced in the bone marrow from precursor monoblasts and usually circulates in the bloodstream for 1 to 3 days before clustering in the spleen as reserve or entering tissues and maturing into macrophages or dendritic cells. They usually constitute 3 to 8% of circulating leukocytes. Monocytosis…

Castleman's disease (angiofollicular hyperplasia)

I. What every physician needs to know. Castleman’s disease, also known as angiofollicular hyperplasia, is a rare and benign disorder of lymph node proliferation coined by the American pathologist Benjamin Castleman in 1965. Specifically, it is defined as a follicular hyperplasia of lymph nodes with abnormally increased vascularity. It can be classified as unicentric or…

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