Cancer Vaccine mRNA-4157 Improves RFS, DMFS in High-Risk Melanoma
Adding the mRNA-4157 vaccine to pembrolizumab improved recurrence-free and distant metastasis-free survival in patients with high-risk, resected melanoma in a phase 2 trial.
All articles by Roi Perez
Sacituzumab Govitecan Improves OS and PFS in HR+, HER2- Metastatic Breast Cancer
Sacituzumab govitecan improves outcomes vs physician’s choice of treatment in patients with endocrine-resistant, HR+, HER2- metastatic breast cancer, results from the phase 3 TROPiCS-02 study suggest.
Perioperative Toripalimab and Chemo Deemed Potential Standard Care in Stage III NSCLC
Perioperative toripalimab plus chemotherapy improves event-free survival over chemotherapy alone in stage III non-small cell lung cancer, a phase 3 study suggests.
Adjuvant Osimertinib Improves OS in EGFR-Mutant, Early-Stage NSCLC
The ADAURA trial is the first global phase 3 study to show an overall survival benefit with targeted treatment in resected, EGFR-mutated, stage IB-IIIA non-small-cell lung cancer, according to study presenter Roy S. Herbst, MD, PhD.
Vorasidenib May Be New Standard Care for IDH1/2-Mutated Glioma
If approved, vorasidenib could become a new standard of care for low-grade IDH1/2-mutated gliomas, according to an ASCO discussant.
Neoadjuvant Nivolumab Plus Relatlimab Appears Safe and Effective in NSCLC
Curative surgery for non-small cell lung cancer after treatment with nivolumab plus relatlimab is as safe as surgery after nivolumab alone, the NEOpredict-Lung study suggests.
Some Patients With HER2+ Early Breast Cancer Can Safely Forgo Chemotherapy
Some patients with early HER2-positive breast cancer can safely forgo neoadjuvant chemotherapy, results of the PHERGain trial suggest.
UCPVax Prompts Immune Responses in MGMT Unmethylated Glioblastoma
UCPVax, an anti-telomerase vaccine, has demonstrated immunogenicity in a phase 2 trial of patients with MGMT unmethylated glioblastoma.
Luspatercept Outperforms ESA in Adults With Lower-Risk MDS
Luspatercept appears more effective than epoetin alfa for treating anemia in patients with ESA-naïve, transfusion-dependent, lower-risk MDS.
Pain and Functional Status Predict Malnutrition in Elderly Women With Breast Cancer
Elderly women with breast cancer who report pain or have impaired functional status should be screened for malnutrition, a study suggests.
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