Non-infectious complications Post-BM/PSC Transplant: Sinusoidal Obstructive Syndrome (SOS)
1. Description of the problem Sinusoidal obstructive syndrome (SOS), initially called veno-occlusive disease (VOD), is a frequent complication of SCT associated with the use of high-dose chemotherapy and radiation. It results in hepatomegaly, fluid retention and ascites, and cholestasis. Although most patients recover from SOS, almost all patients with severe disease will die from disease-related…