1. Description of the problem Sinusoidal obstructive syndrome (SOS), initially called veno-occlusive disease (VOD), is a frequent complication of SCT associated with the use of high-dose chemotherapy and radiation. It results in hepatomegaly, fluid retention and ascites, and cholestasis. Although most patients recover from SOS, almost all patients with severe disease will die from disease-related…
Post-transplant lymphoproliferative disease (PTLD) Synonyms Continue Reading Post-transplant lymphoproliferative disorder, post-transplant lymphoma 1. Description of the problem PTLD is the most common secondary malignancy within the first year after hematopoietic cell transplantation (HCT). PTLD occurs as a result of the proliferation of Epstein-Barr virus (EBV)-transformed B cells in the absence of EBV-specific T-cell immunity. Clinical…
Interstitial pneumonitis Synonym Continue Reading Idiopathic pneumonia syndrome (IPS) Related conditions Diffuse alveolar hemorrhage, peri-engraftment respiratory distress syndrome (PERDS) 1. Description of the problem Interstitial Pneumonitis (IP) is a relatively common (5-15%) complication occurring early after allogeneic hematopoietic cell transplant (HCT) and is characterized by widespread alveolar injury in the absence of lower respiratory tract…
Thrombotic microangiopathy (TMA) Synonyms Continue Reading Thrombotic thrombocytopenic purpura (TTP); hemolytic uremic syndrome (HUS) Related conditions Renal failure Drug toxicity 1. Description of the problem Thrombotic microangiopathy (TMA) after allogeneic SCT can result from many causes, including the use of calcineurin inhibitors (CNI) (most common), high-dose chemotherapy or radiation, or infections. The clinical spectrum for…
Graft failure Synonym Continue Reading Graft rejection Related conditions Marrow aplasia Pancytopenia 1. Description of the problem Graft failure and graft rejection are life-threatening complications after allogeneic SCT. This results in pancytopenia and a high risk of infection and bleeding complications. The risk of graft failure or rejection has decreased over the years with more…
