David Porter, Author at Cancer Therapy Advisor

David Porter

All articles by David Porter

Non-infectious complications Post-BM/PSC Transplant: Sinusoidal Obstructive Syndrome (SOS)

1. Description of the problem Sinusoidal obstructive syndrome (SOS), initially called veno-occlusive disease (VOD), is a frequent complication of SCT associated with the use of high-dose chemotherapy and radiation. It results in hepatomegaly, fluid retention and ascites, and cholestasis. Although most patients recover from SOS, almost all patients with severe disease will die from disease-related…

Non-infectious complications Post-BM/PSC Transplant: PTLD

Post-transplant lymphoproliferative disease (PTLD) Synonyms Post-transplant lymphoproliferative disorder, post-transplant lymphoma 1. Description of the problem PTLD is the most common secondary malignancy within the first year after hematopoietic cell transplantation (HCT). PTLD occurs as a result of the proliferation of Epstein-Barr virus (EBV)-transformed B cells in the absence of EBV-specific T-cell immunity. Clinical features of…

Non-infectious complications Post-BM/PSC Transplant: Interstitial pneumonitis, idiopathic pneumonia syndrome

Interstitial pneumonitis Synonym Idiopathic pneumonia syndrome (IPS) Related conditions Diffuse alveolar hemorrhage, peri-engraftment respiratory distress syndrome (PERDS) 1. Description of the problem Interstitial Pneumonitis (IP) is a relatively common (5-15%) complication occurring early after allogeneic hematopoietic cell transplant (HCT) and is characterized by widespread alveolar injury in the absence of lower respiratory tract infection or…

Non-infectious complications Post-BM/PSC Transplant: Hemolytic uremic syndrome, TTP, Thrombotic microangiopathy

Thrombotic microangiopathy (TMA) Synonyms Thrombotic thrombocytopenic purpura (TTP); hemolytic uremic syndrome (HUS) Related conditions Renal failure Drug toxicity 1. Description of the problem Thrombotic microangiopathy (TMA) after allogeneic SCT can result from many causes, including the use of calcineurin inhibitors (CNI) (most common), high-dose chemotherapy or radiation, or infections. The clinical spectrum for the TMA…

Non-infectious complications Post-BM/PSC Transplant: Graft rejection/graft failure

Graft failure Synonym Graft rejection Related conditions Marrow aplasia Pancytopenia 1. Description of the problem Graft failure and graft rejection are life-threatening complications after allogeneic SCT. This results in pancytopenia and a high risk of infection and bleeding complications. The risk of graft failure or rejection has decreased over the years with more effective transplant…

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