Sideroblastic anemia What every physician needs to know about sideroblastic anemia: Sideroblastic anemias are characterized by the presence of abundant ringed sideroblasts. Ringed sideroblasts are erythroblasts containing a perinuclear collar distribution of iron laden granules (siderotic granules) surrounding the nucleus. This distribution is due to the fact that these granules are being deposited in mitochondria…
Anemia What every physician needs to know about anemia: Anemia (defined as a reduction in the number of circulating red blood cells below normal limits for age and gender) is among the most common abnormalities encountered in medicine. Anemia is recognized as a low hematocrit, hemoglobin, or red blood cell count value. Hematocrit is the…
Methemoglobinemia What every physician needs to know about methemoglobinemia: Methemoglobinemia is a condition in which the oxidation/reduction state of hemoglobin iron is pathologically altered, as described below. It can result from rare congenital abnormalities in the redox system of the red cell, or from toxic oxygen exposure. Those exposures, if of sufficient magnitude, can be…
