John Sladky, Author at Cancer Therapy Advisor

John Sladky

All articles by John Sladky

Neuromuscular Weakness in Children: Transverse Myelitis

Transverse myelitis 1. Description of the problem Acute transverse myelitis (ATM) historically connotes a non-infectious, inflammatory process involving, predominantly, sensory and motor myelinated pathways within the spinal cord. In contrast with poliomyelitis, the disorder tends toward symmetrical involvement of the spinal cord. Pain is often a herald symptom, often maximal around the level of inflammation…

Neuromuscular Weakness in Children: Botulism

Botulism Synonyms Clostridium botulinum toxico-infection Infant Botulism Food Botulism Wound Botulism 1. Description of the problem What every clinician needs to know Intoxication with botulinum toxin occurs through two routes: (1) ingestion of the pre-formed toxin in food botulism; and (2) toxico-infection of the host as in wound botulism. In infant and food botulism, botulinum…

Neuromuscular Weakness in Children: Myelitis

Myelitis Synonyms Poliomyelitis Transverse myelitis Myelopathy 1. Description of the problem What every clinician needs to know Myelitis is a useful but generic term to denote inflammation within the spinal cord. The etiology can be direct invasion of spinal cord parenchyma by infectious pathogens or an autoimmune process triggered by remote infection or other events.…

Neuromuscular Weakness in Children: Myasthenia

Myasthenia 1. Description of the problem What every clinician needs to know The term myasthenia applies to a group of disorders that have in common a defect in acetyl choline mediated neuromuscular transmission. The largest category is myasthenia gravis, an acquired autoimmune disease that results in antibody mediated injury to the post synaptic acetylcholine receptor…

Neuromuscular Weakness in Children: Guillain-Barre Syndrome

Guillain-Barre syndrome Synonyms Acute Inflammatory Demyelinating Polyneuropathy (AIDP) Acute Motor and Sensory Axonal Neuropathy (AMSAN) Acute Motor Axonal Neuropathy (AMAN) Related conditions Miller-Fisher Syndrome – ophthalmoparesis, ataxia and areflexia Polyneuritis Cranialis – multiple cranial neuropathies Acute Pandysautonomia – orthostasis, syncope, autonomic dysfunction 1. Description of the problem What every clinician needs to know Guillain-Barre syndrome…

Next post in Critical Care Medicine