Familial Defective Apolipoprotein B-100 (FDB)
At a Glance Familial defective apolipoprotein B-100 (FDB) is a phenocopy of familial hypercholesterolemia (FH) and a significant cause of coronary heart disease (CHD). This fairly common cause of FH is an autosomal dominant disorder caused by mutations in the ligand-binding domain (exon 26) of the APOB gene on chromosome 2p24.1 that result in defective…