Katherine A. Hajjar

Disorders of fibrinolysis What every physician needs to know: Isolated primary deficiencies of fibrinolytic factors (plasminogen, tissue plasminogen activator [tPA], and urokinase [uPA]) rarely cause intravascular thrombosis. On the other hand, overall functional fibrinolytic deficiency, as measured by appropriate clot lysis assays, has recently been shown to be a weak risk factor for thrombosis, and…