Differential Diagnosis Elevated total cholesterol Elevated LDL cholesterol Continue Reading Decreased HDL cholesterol Increased fasting triglyceride Suggested Additional Lab Testing Total cholesterol level Can be performed on serum or plasma Can be obtained fasting or non-fasting HDL cholesterol Can be performed on serum or plasma Can be obtained fasting or non-fasting LDL cholesterol level Pt…
Differential Diagnosis Acquired causes of platelet dysfunction: Ingestion of aspirin or aspirin-like compounds or NSAIDs Impaired renal functionContinue Reading Myeloproliferative disease Exposure to cardiopulmonary bypass Presence of a paraprotein Congenital causes of platelet dysfunction: Storage pool disease Glanzmann thrombasthenia Bernard-Soulier syndrome Disorders of thromboxane production or action Suggested Additional Lab Testing Platelet aggregation studies with…
Differential Diagnosis If the diseases in the list below increase in severity, there may be findings suggestive of cirrhosis with or without hepatic failure: Viral hepatitis, multiple forms (see chapters on Viral Hepatitis A, B, and C) HemochromatosisContinue Reading Wilson disease Alpha-1-antitrypsin deficiency Hepatocellular carcinoma Suggested Additional Lab Testing Total bilirubin and unconjugated bilirubin are…
Differential Diagnosis Presence of factor V Leiden (can be heterozygous or homozygous) Presence of prothrombin 20210 mutation (can be heterozygous or homozygous) Continue Reading Presence of antiphospholipid antibody; could be manifested as lupus anticoagulant or anticardiolipin antibodies or anti-beta 2 glycoprotein 1 antibodies (IgG, IgM, IgA) Elevated homocysteine Deficiency of protein C not produced by…
Differential Diagnosis Red blood cell (RBC) hemolysis from a variety of causes Obstruction of the biliary tract from any of the several possibilities Continue Reading Intrahepatic biliary diseases: primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) Hereditary conjugated hyperbilirubinemias: Dubin-Johnson syndrome, Rotor syndrome Hereditary unconjugated hyperbilirubinemias: Criggler-Najjar syndrome type I, Criggler-Najjar syndrome type II, Gilbert…
At a Glance Antiphospholipid antibodies include anticardiolipin antibodies, the lupus anticoagulant, and antibeta-2 glycoprotein 1 antibodies. The current classification criteria for antiphospholipid syndrome include both laboratory criteria and clinical criteria. The laboratory criteria are the presence of an elevated concentration of antiphospholipid antibodies, which includes a positive test for the lupus anticoagulant, present on 2…
At a Glance Glycoprotein IIb/IIIa inhibitors in clinical use include tirofiban (Aggrastat), eptifibatide (Integrilin), and abciximab (ReoPro). These compounds are very potent antiplatelet agents. They are commonly used in procedures involving cardiac catheterization. In a small percentage of cases, these drugs can also induce a significant thrombocytopenia, with platelet counts often less than 10,000 per…
At a Glance In the vast majority of cases of von Willebrand disease, the disease is an inherited bleeding disorder. Only very rare acquired cases arise in association with multiple myeloma and related disorders, as a result of neutralizing antibodies to von Willebrand factor, or in patients with aortic stenosis in which there is destruction…
At a Glance Von Willebrand disease is an inherited bleeding disorder with only very rare acquired cases. A family history of bleeding, especially one that affects both males and females, should prompt consideration of von Willebrand disease. Because it is a mild bleeding disorder in most patients, many patients report a negative bleeding history. The…
At a Glance Antiplasmin is the natural inhibitor of the proteolytic enzyme plasmin, which is generated from the activation of plasminogen. In the absence of antiplasmin, the proteolytic enzyme plasmin excessively degrades fibrin clots, while it also degrades proteins on the platelet surface and in the circulation, including the coagulation factors. It is for this…
