Mihaela Chiselite

At a Glance Plasma cell myeloma is a bone marrow-based clonal plasma cell proliferation. It comprises 10-15% of hematopoietic neoplasms. It is typically diagnosed as a result of evaluations for anemia, renal failure, and/or bone lytic lesions. When serum or urine protein electrophoresis studies detect a monoclonal immunoglobulin (paraprotein, M-protein) secreted by these neoplasms, the…

At a Glance Anaplastic large cell lymphoma (ALCL) is a type of T cell lymphoma characterized by large, bizarre, pleomorphic neoplastic cells with abundant cytoplasm (referred to as “Hallmark cells”). However, there is a wide morphologic spectrum with a “small cell” pattern also described. In the latest 2008 classification, the World Health Organization (WHO) has…

At a Glance Primary cutaneous anaplastic large cell lymphoma is a primary cutaneous CD30 positive T-cell lymphoproliferative disorder. Lymphomatoid papulosis is a more indolent and self-healing condition. Cutaneous anaplastic large cell lymphoma is a type of cutaneous T-cell lymphoma. What Tests Should I Request to Confirm My Clinical Dx? In addition, what follow-up tests might…

At a Glance Plasmablastic lymphoma (PBL) is an uncommon, highly aggressive type of lymphoma, which classically has been described with the highest incidence in HIV-positive individuals (typically presenting as a mass within the oral cavity; “oral cavity type”). However, it can present in other mucosal sites (i.e., Sinonasal, orbit, long, gastrointestinal (GI) tract), skin, and…

At a Glance Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas with a diffuse pattern of growth, composed of large cells with open/vesicular nuclear chromatin, and a nuclear size at least double the size of a normal lymphocyte nucleus or equal or greater to a normal histiocyte nucleus. DLBCL is one…