Myelodysplastic Syndromes
Myelodysplastic Syndromes I. What every physician needs to know. Myelodyplastic Syndromes (MDS) is an acquired marrow failure syndrome caused by accumulated mutations in pluripotent stem cells responsible for production of blood cells. The mutations lead to ineffective dysplastic hematopoiesis. Most cases of MDS arise denovo with a smaller number (~15%) secondary to exposure to DNA-damaging…