Stacy E. F. Melanson

Differential Diagnosis Acquired causes of platelet dysfunction: Ingestion of aspirin or aspirin-like compounds or NSAIDs Impaired renal functionContinue Reading Myeloproliferative disease Exposure to cardiopulmonary bypass Presence of a paraprotein Congenital causes of platelet dysfunction: Storage pool disease Glanzmann thrombasthenia Bernard-Soulier syndrome Disorders of thromboxane production or action Suggested Additional Lab Testing Platelet aggregation studies with…

Differential Diagnosis If the diseases in the list below increase in severity, there may be findings suggestive of cirrhosis with or without hepatic failure: Viral hepatitis, multiple forms (see chapters on Viral Hepatitis A, B, and C) HemochromatosisContinue Reading Wilson disease Alpha-1-antitrypsin deficiency Hepatocellular carcinoma Suggested Additional Lab Testing Total bilirubin and unconjugated bilirubin are…

Differential Diagnosis Red blood cell (RBC) hemolysis from a variety of causes Obstruction of the biliary tract from any of the several possibilities Continue Reading Intrahepatic biliary diseases: primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) Hereditary conjugated hyperbilirubinemias: Dubin-Johnson syndrome, Rotor syndrome Hereditary unconjugated hyperbilirubinemias: Criggler-Najjar syndrome type I, Criggler-Najjar syndrome type II, Gilbert…

Differential Diagnosis Presence of factor V Leiden (can be heterozygous or homozygous) Presence of prothrombin 20210 mutation (can be heterozygous or homozygous) Continue Reading Presence of antiphospholipid antibody; could be manifested as lupus anticoagulant or anticardiolipin antibodies or anti-beta 2 glycoprotein 1 antibodies (IgG, IgM, IgA) Elevated homocysteine Deficiency of protein C not produced by…