Are You Confident of the Diagnosis? Elastosis perforans serpiginosa (EPS) represents a distinct entity within the spectrum of perforating dermatoses. It is a rare disorder characterized by transepidermal elimination of altered elastic fibers. About one-quarter of cases are associated with an underlying disorder, typically of connective tissue, or with D-penicillamine use. These include Marfan syndrome,…
Are You Confident of the Diagnosis? In order to be confident in the diagnosis of a perforating disorder, one must acknowledge the historical ambiguity in classifying these disorders. In the past, these disorders have included elastosis perforans serpiginosum (EPS), reactive perforating collagenosis (RPC, pediatric and adult forms), perforating folliculitis (PF), Kyrle’s disease, perforating disorder of…
Are You Confident of the Diagnosis? What you should be alert for in the history A history of diabetes, renal or hepatic disease, and congestive heart failure have been reported as associations with Kyrle’s disease. Up to 10% of renal dialysis patients develop Kyrle’s disease. However, other authors deny any such systemic associations. Curiously, Kyrle’s…
