Phase 3 Trial for Oncolytic Viral Therapy Pexa-Vec in Advanced Liver Cancer Terminated Early
Pexa-Vec, in combination with sorafenib, has failed an interim futility analysis, leading to the early termination of the trial.
All articles by Victoria Forster, PhD
Personalized Cancer Vaccine NEO-PV-01 Shows Promise in 3 Types of Advanced Cancer
Early results from a clinical trial of personalized cancer vaccine NEO-PV-01 in 3 types of advanced cancer have shown promise and no significant toxicity issues.
Female Childhood Cancer Survivors Are at Increased Risk for Breast Cancer Due to Anthracycline Treatment
Survivors of childhood cancers who were treated with anthracyclines are at increased risk for developing breast cancer.
Disrupted Glucose Metabolism Led to High Levels of DNA Damage in Pancreatic Tissue: Study
A new study has suggested disrupted glucose metabolism is linked to high levels of DNA damage in the pancreas, which may contribute to the acquisition of KRAS mutations and subsequent carcinogenesis.
CAR-T Therapy Injected Directly Into Chest Cavity Shows Early Promise in Pleural Cancers
Early results from a phase 1 clinical trial of CAR T cells administered directly into the chest cavity for the treatment of pleural cancers has shown low toxicity and high efficacy.
Tumors With High Levels of Microsatellite Instability Responded Well to Treatment With PD-1 Inhibitors
New research has linked microsatellite instability and the number of insertion/deletion mutations present in a tumor to clinical response to checkpoint inhibition.
Personalized Cancer Vaccine NEO-PV-01 Shows Promise in Early Trials in Advanced Melanoma
Early results from a small clinical trial of a new personalized cancer vaccine called NEO-PV-01 in advanced melanoma appear promising — and no significant toxicity issues have yet been revealed.
Muscle Complaints Are a Frequent Side Effect of TKI Use in CML, but What Causes Them?
Many CML patients on TKI treatment report muscle complaints, but there has been little work to find out why. A new study sought to find out more about the nature of these complaints and to undercover a biological mechanism to explain them.
Can Patient-Derived Organoids Help Oncologists Make Treatment Decisions?
Organoids created from tumor samples have been revolutionizing laboratory research, but they also may begin helping oncologists decide on treatment regimens for patients.
Drug Shortages Threaten Childhood Cancer Treatment
Experts are calling for a protected drugs list to stop shortages that could impact the chance of survival for childhood cancer patients.
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