Phase 2 Study of Imatinib Shows Activity in Advanced Chordoma

Share this content:

(ChemotherapyAdvisor) – The largest Phase 2 study in patients with chordoma to date “confirms anecdotal evidence that imatinib has antitumor activity in this orphan disease, and therefore, it is worth further investigation,” according to a study in the Journal of Clinical Oncology published online February 13.

In the study, 56 patients with advanced platelet-derived growth factor-beta (PDGFB)/PDGF receptor beta (PDGFRB)–positive chordomas received imatinib 800mg/day until disease progression. The best response among 50 patients evaluable by RECIST was one partial response obtained at six months (overall tumor response rate, 2%); 35 patients (70%) had stable disease, for a clinical benefit rate of 64%.

A minor dimensional response (<20%) was detected in 9 patients, and a maximum standard uptake value decrease ≥25% was observed in 10 of 26 patients (39%) evaluable for PET response at three months. Median progression-free survival was nine months. No unexpected toxicities were observed. Changes in the Brief Pain Inventory score were consistent with the response assessment.

“This is a new achievement in an orphan disease devoid of any standard medical therapy,” the authors wrote, adding that lack of response and the potential slow natural course of the disease “do not allow us to affirm that this treatment is effective.”

Abstract

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs