TTFields Prolong Overall Survival in Glioblastoma
Adding Tumor Treating Fields (TTFields) to maintenance temozolomide significantly prolongs both median and long-term survival.
Among patients with newly diagnosed glioblastoma multiforme, adding Tumor Treating Fields (TTFields) to maintenance temozolomide significantly prolongs both median and long-term survival, according to a study presented 21st Annual Scientific Meeting of the Society of Neuro-Oncology (SNO).1
TTFields is a frequency-tuned, anti-mitotic, physical treatment modality delivered to the brain through a patient-operated, portable medical device called Optune. Results of a pre-specific successful interim analysis of the international, phase 3 trial (ClinicalTrials.gov Identifier: NCT00916409) comparing TTFields and temozolomide with temozolomide alone after radiotherapy and adjuvant temozolomide led to the approval of TTFields for the treatment of adult patients with glioblastoma.
A mature analysis of 695 patients with a median follow-up of 36 months showed that adding TTFields to temozolomide significantly reduces the risk of progression or death by 37% compared with temozolomide alone (hazard ratio [HR], 0.63; P < .00005). Median progression-free survival was 6.7 months (95% CI, 6.1-8.1) with TTFields and 4.0 months (95% CI, 3.8-4.3) with temozolomide alone.
Researchers also found that treatment with TTFields reduced the risk of death by 35% vs maintenance temozolomide alone (HR, 0.65; 95% CI, 0.54-0.79; P < .00062); median overall survival from randomization was 21 months and 16 months, respectively.
The 2-year, 3-year, and 4-year survival rates were also significantly better for patients in the TTFields arm (P < .05 for all time points).
Within 7 weeks after the end of radiation treatment and adjuvant temozolomide, newly diagnosed patients with non-progressive disease were randomly assigned 2:1 to temozolomide 5 days per week plus continuous administration of TTFields or temozolomide alone.
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Additional studies are enrolling patients to evaluate TTFields in combination with bevacizumab with or without temozolomide in recurrent glioblastoma, as well as in other forms of cancer.
- Stupp R, Idbaih A, Steinberg DM, et al. Prospective, multi-center phase III trial of Tumor Treating Fields together with temozolomide compared to temozolomide alone in patients with newly diagnosed glioblastoma. Neuro Oncol. 2016;18(suppl 6):i1.