Study Classifies Gliomas Based on Tumor Markers

Share this content:
Gliomas classified by tumor markers were characterized by distinct mechanisms of pathogenesis, ages at onset and overall survival.
Gliomas classified by tumor markers were characterized by distinct mechanisms of pathogenesis, ages at onset and overall survival.

Gliomas classified by tumor markers were characterized by distinct mechanisms of pathogenesis, ages at onset, overall survival, and associations with germline variants, a new study published online ahead of print in The New England Journal of Medicine has shown.

For the study, researchers analyzed 1,087 gliomas as positive or negative for mutations in the TERT promoter, mutations in IDH, and codeletion of chromosome arms 1p and 19q, and classified them into five primary molecular groups. Researchers then compared associations between those groups and known glioma germline variants.

Gliomas were classified as being triple-positive, having TERT and IDH mutations, having only IDH mutations, having only TERT mutations, and being triple-negative.

Results showed that the average age at the time of diagnosis was lowest among those who had only IDH mutations. Age at onset was highest among patients who had gliomas with only TERT mutations.

RELATED: Efficacy of Chemotherapy Similar to Radiotherapy for Anaplastic Glioma

Researchers found that the molecular groups were independently associated with overall survival among those with grade II or III gliomas, but not grade IV gliomas. The study also demonstrated that the molecular groups were associated with specific germline variants.

The findings may ultimately better inform patient management and treatment decisions of patients with gliomas.

Reference

  1. Eckel-Passow JE, Lachance DH, Molinaro AM, et al. Glioma groups based on 1p/19q, IDH, and TERT promoter mutations in tumors. N Engl J Med. 2015. [Epub ahead of print]. doi: 10.1056/NEJMoa1407279.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs