Nimotuzumab Not Clinically Efficacious in Glioblastoma
the Cancer Therapy Advisor take:
Glioblastoma (GBM) is a type of highly malignant brain tumor with poor prognosis. Epidermal growth factor receptors (EGF-R) have been linked to the oncogenesis of GBM, in which the EGF-RvIII variant is most commonly seen.
Agents targeting EGF-R, such as gefitnib and erlotnib, and monoclonal antibodies like cetuximab, have not demonstrated convincing efficacy for the treatment of GBM, however, antibody mediated therapy and vaccinations are being explored.
Nimotuzumab, a monoclonal antibody that has a greater specificity for EGF-R overexpressing cells compared to cetuximab, has shown promising efficacy for high grade glioma. Investigators conducted a randomized, open label trial to evaluate the efficacy of nimotuzumab in patients with newly diagnosed glioblastoma.
There were 149 patients in the study, stratified as with or without residual tumor, and were randomly assigned to receive either intravenous nimotuzumab added to standard radiotherapy or just standard radiotherapy.
Results showed that the 12-month PFS was seen in 25.6% of patients in the nimotuzumab group, and 20.3% in the control group. Of the patients with residual tumor (n=81), the median PFS was 5.6 months in the nimotuzumab group versus 4.0 months in the control group (HR 0.87; 95%CI, 0.55-1.37), and patients without residual tumor (n=61) 10.6 versus 9.9 months (HR, 1.01; 95%CI, 0.57-1.77).
The median OS in patients with residual tumor was 19.5 months in the nimotuzumab group versus 16.7 months in the control group (HR, 0.90; 95% CI, 0.52-1.57; P=0.7061), and patients without residual tumor 23.3 versus 21.0 months (HR, 0.77; 95% CI, 0.41-1.44; P=0.4068).
A cohort study was conducted on MGMT non-methylated patients with residual tumor and showed a PFS of 6.2 versus 4.0 months (HR, 0.77; 95% CI, 0.35-1.67; P=0.4997), and OS of 19.0 versus 13.8 months (HR, 0.66; 95% CI, 0.27-1.64; P=0.3648).
The authors concluded that EGF-R amplification does not correlate with clinical efficacy of nimotuzumab, and thus alternative explanations should be hypothesized for the treatment of GBM. The results of this study provided important information to plan for future trials.
Nimotuzumab has shown promising efficacy for high grade glioma.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- A Vegan Diet and Cancer
- As HPV-Related Cancer Rates Climb, Experts Scrutinize Barriers to HPV Vaccination
- Bowel Preparation for Colorectal Cancer Screening: Improving Outcomes
- Ponatinib Tops Bosutinib for Third-Line Treatment of CML in a Comparative Analysis
- Duvelisib Delayed Progression in CLL/SLL: Study
- FDA-Approved Breast Cancer Drug Treatments
- A Trained Dog Smells Early-Stage Lung Cancer With a High Degree of Accuracy
- FDA-Approved Prostate Cancer Drug Treatments
- FDA-Approved Colorectal Cancer Drug Treatments
- Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?
- Potential Diagnostic Tool Detects BCR-ABL1 mRNA in Chronic Myeloid Leukemia
- BTK Inhibitor Zanubrutinib Appears Promising in Waldenström Macroglobulinemia
- Carfilzomib Regimens Offer a Neuropathy-Sparing Approach in Multiple Myeloma, WM
- Apalutamide Does Not Diminish Quality of Life in Nonmetastatic Castration-Resistant Prostate Cancer
- Treatment Delays May Mean Worse Survival in Head and Neck Cancer