Weekly Vinblastine Reasonable in Children with Relapsed Low-Grade Glioma

Share this content:

(ChemotherapyAdvisor) – Weekly vinblastine appears to be a “reasonable alternative to radiation” for the treatment of children with recurrent or refractory low-grade glioma after failure of first-line chemotherapy, results of a Phase 2 trial published in Journal of Clinical Oncology online March 5 have found.

The study enrolled 51 patients who had experienced a previous treatment failure (chemotherapy and/or radiation) for incompletely resected or unresectable low-grade glioma. Fifty patients had previously received at least one prior regimen of chemotherapy and ten, radiation therapy. Median age was 7.2 years (range, 1.4 to 18.2 years). Vinblastine 6mg/m2 was administered weekly for one year until disease progression or unacceptable toxicity.

Of the 50 patients evaluable for response, 18 (36%) had a complete, partial, or minor response; 31 completed one year of treatment. At a median follow-up of 67 months, 23 patients had not experienced progression and three patients had died. Five-year overall survival was 93.2%. Toxicity was primarily hematologic; a few patients needed transfusions.

Five-year progression-free survival among the patients treated with weekly vinblastine — 42.3% — was comparable to that observed with first-line chemotherapy in chemotherapy-naïve patients.


Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs