BRCA

Most US Women Undergoing BRCA Testing Not Receiving Genetic Counseling

Most US Women Undergoing BRCA Testing Not Receiving Genetic Counseling

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Most US women undergoing BRCA genetic testing do not receive genetic counseling despite multiple guidelines.

Universal Genetic Testing for Breast Cancer May Not be Good Policy

Universal Genetic Testing for Breast Cancer May Not be Good Policy

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Although a broad BRCA-1/2 genetic testing program has been suggested for all US women, it is not recommended due to cost and lack of benefit.

Multigene Testing Identifies More Mutations in Breast, Ovarian Cancer

Multigene Testing Identifies More Mutations in Breast, Ovarian Cancer

Multigene testing for hereditary breast and/or ovarian cancer (HBOC) identifies more mutations that are likely to change clinical management.

Breast, Ovarian Cancer Risk Varies with BRCA Mutation Location

Breast, Ovarian Cancer Risk Varies with BRCA Mutation Location

The risk of breast and ovarian cancer varies with the type and location of BRCA1/2 mutations.

Correlated Spectroscopy Can Identify Changes in BRCA Carriers

Correlated Spectroscopy Can Identify Changes in BRCA Carriers

Use of localized correlated spectroscopy (COSY) shows significant changes in women with BRCA1 and BRCA2 mutations.

Carboplatin Associated with Better Outcomes than Docetaxel in Advanced BRCA1/2-mutation Breast Cancer

Carboplatin Associated with Better Outcomes than Docetaxel in Advanced BRCA1/2-mutation Breast Cancer

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Carboplatin is associated with better outcomes than docetaxel in individuals with BRCA1/2 mutation-harboring breast cancer.

Telephone Support Intervention Beneficial in BRCA Carriers

Telephone Support Intervention Beneficial in BRCA Carriers

Reduction in BRCA mutation distress in breast cancer patients, unmet information needs with telephone-based, peer-support program.

Olaparib May Be Effective for Advanced Cancers Associated with BRCA Mutations

Olaparib May Be Effective for Advanced Cancers Associated with BRCA Mutations

Olaparib may be effective for the treatment of numerous advanced cancers caused by BRCA1 and BRCA2 mutations.

Angelina Jolie Coverage Boosted BRCA Testing for Breast Cancer

Angelina Jolie Coverage Boosted BRCA Testing for Breast Cancer

Celebrity story helped double rates of genetic testing in following six months at one cancer center.

New Gene Linked to Increased Risk of Breast Cancer

New Gene Linked to Increased Risk of Breast Cancer

Mutated versions of a gene called PALB2 can dramatically increase a woman's risk of breast cancer, a new study has found.

Genetic Testing Influences Surgical Decisions in Breast Cancer

Genetic Testing Influences Surgical Decisions in Breast Cancer

Majority of BRCA mutation carriers opted for different surgery than initially planned by their surgeons.

Cancer Risk Modifiers in BRCA1/2 Carriers Identified

Cancer Risk Modifiers in BRCA1/2 Carriers Identified

Modifiers of cancer risk have been identified for BRCA1/2 mutation carriers, according to a review published online.

Multiple-Gene Sequencing IDs Mutations in Non-BRCA Carriers

Multiple-Gene Sequencing IDs Mutations in Non-BRCA Carriers

A considerable number of women testing negative for BRCA1/2 may have pathogenic mutations in other genes.

Dust Hasn't Settled on Supreme Court's Gene Patent Ruling

Dust Hasn't Settled on Supreme Court's Gene Patent Ruling

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Although dire predictions about the ruling on the biotech industry and health care have not come to pass, questions remain regarding the sequence-interpreting experience of the new crop of BRCA testing labs.

Women With BRCA Mutations Shouldn't Delay Oophorectomy

Women With BRCA Mutations Shouldn't Delay Oophorectomy

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For women with a BRCA mutation, delaying oophorectomy beyond age 35 sharply increases the risk of cancer and mortality.

BRCA Mutation Risk Underestimated by BRCAPRO Model

BRCA Mutation Risk Underestimated by BRCAPRO Model

More mutations observed than expected at BRCAPRO scores of less than 40%.

New Study May Pave Way for Detecting Ovarian Cancer Earlier

New Study May Pave Way for Detecting Ovarian Cancer Earlier

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Research has revealed new genetic variants in patients with ovarian cancer that may eventually help detect the disease earlier.

Earlier Ovary Removal Better for BRCA Carriers

Earlier Ovary Removal Better for BRCA Carriers

Oophorectomy reduces the risk of developing ovarian, fallopian tube, or peritoneal cancer by 70% in women with BRCA mutations.

BRCA Carriers Morely Likely to Survive with Bilateral Mastectomy

BRCA Carriers Morely Likely to Survive with Bilateral Mastectomy

Women with BRCA mutations and early-stage breast cancer who underwent bilateral mastectomy vs. unilateral mastectomy are less likely to die from the disease.

Telephone Effective for BRCA 1/2 Genetic Counseling

Telephone Effective for BRCA 1/2 Genetic Counseling

Genetic counseling for BRCA 1/2 gene testing delivered via telephone was not inferior to in-person counseling with respect to knowledge gained and perceived stress.

IMPACT Study Supports Targeted PSA Screening Based on BRCA1/2 Mutations

IMPACT Study Supports Targeted PSA Screening Based on BRCA1/2 Mutations

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Preliminary results from the IMPACT study support the use of targeted PSA screening based on BRCA genotype.

USPSTF Backs Genetic Counseling for BRCA Mutations

USPSTF Backs Genetic Counseling for BRCA Mutations

Women with a family medical history of BRCA mutations should be offered counseling and genetic testing

Women without the <i>BRCA</i> Mutation but with Family History of  <i>BRCA2</i> Are at Higher Risk for Breast Cancer

Women without the BRCA Mutation but with Family History of BRCA2 Are at Higher Risk for Breast Cancer

Women from BRCA2 families but without the BRCA mutation still have higher breast cancer risk.

Recent News Brings Focus on BRCA Testing and Management

Recent News Brings Focus on BRCA Testing and Management

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Current events have brought to light issues surrounding BRCA gene mutation testing.

How Will the BRCA Patent Ruling Affect Oncology?

How Will the BRCA Patent Ruling Affect Oncology?

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The Supreme Court ruling last week that human genes cannot be patented will lower the cost of BRCA gene tests and open doors to research.

USPSTF Limits BRCA Testing to Women With Family History

USPSTF Limits BRCA Testing to Women With Family History

Women whose family history is not linked to BRCA mutations should not undergo genetic testing, according to a U.S. Preventive Services Task Force recommendation.

Survival Advantage of BRCA Mutations in Ovarian Cancer is Short-Lived

Survival Advantage of BRCA Mutations in Ovarian Cancer is Short-Lived

Survival advantage during three years after diagnosis; no difference in prognosis at 10 years

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