Genomic Testing More Likely to Impact Younger Women

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Younger patients with breast cancer who received the 21-gene recurrence score assay had reduced use of adjuvant chemotheray.
Younger patients with breast cancer who received the 21-gene recurrence score assay had reduced use of adjuvant chemotheray.

Younger patients with breast cancer who received the 21-gene recurrence score (RS) assay had reduced use of adjuvant chemotherapy and had lower health care costs than patients older than 55 years, according to a study published online ahead of print in the Journal of Clinical Oncology.1

In this study, investigators sought to determine the associations between RS, subsequent chemotherapy use, and health care costs.

Investigators used data from the Pennsylvania Cancer Registry to create a group of women with early stage breast cancer who underwent surgical treatment from 2007 to 2010. These data were compared with administrative claims from the 12-month periods before and after diagnosis to identify comorbidities, treatments, and cost (n = 7287).

The effect of RS on chemotherapy use and expenditure the year after diagnosis was estimated by using propensity-score weighted regression models.

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Results showed that age was the biggest determining factor between use of RS and outcomes. Women younger than 55 who used RS had a 19.5% lower rate of chemotherapy administration (95% CI, 10.6 – 27.9). Women between 75 and 84 years who used RS had 5.7% higher rate of chemotherapy use (95% CI, 0.4 – 11.0). Similarly, younger women who used RS had lower medical expenditures than did older women.

Reference

  1. Epstein AJ, Wong Y-N, Mitra N, et al. Adjuvant chemotherapy use and health care costs after introduction of genomic testing in breast cancer [published online ahead of print November 23, 2015]. J Clin Oncol. doi: 10.1200/JCO.2015.61.9023. 

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