Complication Rate Following Postmastectomy Reconstruction Varies by Prodecure

This article originally appeared here.
Share this content:
Study Compares Procedures for Postmastectomy Reconstruction
Study Compares Procedures for Postmastectomy Reconstruction

(HealthDay News) -- For patients undergoing autologous postmastectomy breast reconstruction, the rates of complications vary with different procedures, according to research published in the February issue of the Journal of the American College of Surgeons.

Michael S. Gart, M.D., of the Northwestern Memorial Hospital in Chicago, and colleagues conducted a large-scale, retrospective review of data from 3,296 patients undergoing autologous breast reconstruction from the National Surgical Quality Improvement Program. Complication rates and risk factors for complications and outcomes of interest were compared for free flaps, pedicled transverse rectus abdominis myocutaneous (TRAM) flaps, latissimus, and all flaps in aggregate.

The researchers found that significant predictors of increased complications in autologous reconstruction included American Society of Anesthesiologists classification ≥3, body mass index >30 kg/m², recent surgery, delayed reconstruction, and prolonged operative times. The complication rate, need for reoperation, and rate of flap failure were highest for patients who underwent free tissue transfer. The rate of complications was significantly lower with latissimus flaps compared with other autologous methods. Venous thromboembolic disease and surgical site infections were highest in patients undergoing pedicled TRAM procedures.

"The nationwide use of pedicled flap autologous breast reconstruction remains high, at 81.5 percent. Our multivariate regression analysis showed that the 30-day complication outcomes of pedicled flaps, particularly the latissimus flap, are correspondingly lower than those for free flaps," the authors write. "Integrating this information into the patient-physician dialogue before breast reconstruction will help broaden patient education and guide informed decision-making."

Full Text (subscription or payment may be required)

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs