Weekly Docetaxel Less Effective, More Toxic than CMF in Early Breast Cancer

Share this content:

the Cancer Therapy Advisor take:

According to a new study published in the journal Annals of Oncology, researchers have found that weekly docetaxel is not more effective than standard cyclophosphamide, methotrexate, and fluorouracil (CMF) as adjuvant treatment of older women with breast cancer and worsens toxicity and quality of life.

Because evidence on adjuvant chemotherapy in older women is lacking, researchers sought to determine whether weekly docetaxel is more effective than standard CMF.

For the phase 3 study, researchers enrolled 302 women aged 65-79 and randomly assigned them to receive either docetaxel 35mg/m2 on days 1, 8, and 15 every 4 weeks or cyclophosphamide 600mg/m2, methotrexate 40mg/m2, and fluorouracil 600mg/m2 on days 1 and 8 every 4 weeks. Both treatments were given for four to six cycles according to hormone receptor status.

Results showed after a 70-month median follow-up, the unadjusted hazard ratio of disease-free survival for weekly docetaxel compared with CMF was 1.21 (95% CI: 0.83 - 1.76; P = 0.32). In addition, the hazard ratio of death was 1.34 (95% CI: 0.80 - 2.22; P = 0.26).

Toxicity and quality of life were worse with docetaxel than standard chemotherapy. The findings suggest that weekly docetaxel should not be used in place of standard CMF as adjuvant treatment of older women with breast cancer.

For EGFR-Mutant Non-Squamous Non-Small Cell Lung Cancer, Bevacizumab Plus Chemotherapy Not Effective
Weekly docetaxel is not more effective than standard cyclophosphamide, methotrexate, and fluorouracil in breast cancer.
The authors tested whether weekly docetaxel is more effective than standard chemotherapy. Weekly docetaxel is not more effective than standard CMF as adjuvant treatment of older women with breast cancer and worsens QoL and toxicity.
READ FULL ARTICLE From Mdlinx

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs