Genetic Variants Identified for Risk of Male Breast Cancer

This article originally appeared here.
Share this content:
Genetic Variants Identified for Risk of Male Breast Cancer
Genetic Variants Identified for Risk of Male Breast Cancer

(HealthDay News) -- Two single nucleotide polymorphisms (SNPs) associated with an increased risk of male breast cancer have been identified, according to a study published online Sept. 23 in Nature Genetics.

Nick Orr, Ph.D., from the Institute of Cancer Research in London, and colleagues performed a genome-wide association study of 447,760 autosomal SNPs in 823 men with breast cancer and 2,795 controls of European ancestry.

The researchers identified 17 SNPs associated with male breast cancer that mapped to six independent genomic regions. Two variants retained genome-wide significance after further validation in 438 cases and 474 controls: an SNP in RAD51B at 14q24.1 (odds ratio, 1.57) and an SNP within TOX3 at 16q12.1 (odds ratio, 1.50), which confirmed a previous association seen in a smaller study.

"These data provide evidence for low-penetrance susceptibility to male breast cancer," Orr and colleagues conclude. "Given the modest size of our study, it is likely that additional risk variants can be identified by future genome-wide association studies."


Full Text (subscription or payment may be required)

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs