Incidence of Cardiac Events Low With Adjuvant Trastuzumab

Share this content:
Incidence of Cardiac Events Low With Adjuvant Trastuzumab
Incidence of Cardiac Events Low With Adjuvant Trastuzumab

(HealthDay News) -- The incidence of cardiac outcomes remains low in long-term follow-up of patients who received adjuvant trastuzumab for early-stage breast cancer, according to a study published online in the Journal of Clinical Oncology.

Evandro de Azambuja, MD, PhD, from the Jules Bordet Institute in Brussels, and colleagues assessed 8-year median follow-up data among participants in the Herceptin Adjuvant study. Human epidermal growth factor receptor 2 (HER2)-positive early-stage breast cancer patients had been randomly assigned to 2 years of trastuzumab (1,673 patients), 1 year of trastuzumab (1,682 patients), or observation (1,744 patients).

The researchers found that adverse cardiac events leading to discontinuation of trastuzumab occurred in 9.4% of patients in the 2-year arm and 5.2% of patients in the 1-year arm. 

RELATED: Trastuzumab Ups Cardiac Risk for Older Women With Breast Cancer

All three arms had low levels of cardiac death, severe congestive heart failure (CHF; incidence 0.8%, 0.8%, and 0.0%, respectively), and confirmed significant left ventricular ejection fraction (LVEF) decrease (7.2%, 4.1%, and 0.9%, respectively), but the incidence of severe CHF and confirmed significant LVEF decrease was significantly higher in the 2-year and 1-year trastuzumab arms versus the observation arm.

"Long-term assessment at eight-year median follow-up confirms the low incidence of cardiac events for trastuzumab given sequentially after chemotherapy and radiotherapy, and cardiac events were reversible in the vast majority of patients," concluded the authors.

Several authors disclosed financial ties to the pharmaceutical industry.


  1. de Azambuja E, Procter MJ, van Veldhuisen DJ et al. Trastuzumab-Associated Cardiac Events at 8 Years of Median Follow-Up in the Herceptin Adjuvant Trial (BIG 1-01). J Clin Oncol. 2014;doi:10.1200/JCO.2013.53.9288.

Related Resources

Related Slideshows

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs