Pre-Op Breast Pain in Approximately 28% of Breast Cancer Patients

Share this content:
Pre-Op Breast Pain in ~28 Percent of Breast Cancer Patients
Pre-Op Breast Pain in ~28 Percent of Breast Cancer Patients
(HealthDay News) – More than a quarter of women about to undergo breast cancer surgery experience breast pain, with genetic polymorphisms in inflammatory cytokines correlating with pain, according to a study published in the May issue of The Journal of Pain.

Birha McCann, RN, CNS, of the University of California in San Francisco, and associates recruited 398 women with breast cancer prior to surgery to determine the occurrence rate and characteristics of preoperative breast pain. The women completed self-report questionnaires and were genotyped. Variations in pro- and anti-inflammatory cytokine genes were assessed for those who did and did not report pain.

The researchers found that 28.2% of women self-reported breast pain. These women were significantly younger (P<0.001), were more likely to be nonwhite (P=0.032), were less likely to be postmenopausal (P=0.012), reported lower Karnofsky Performance Status scores (P=0.008), and had undergone more biopsies (P=0.006). Presurgical breast pain was significantly less likely for carriers of the minor allele for a single nucleotide polymorphism in interleukin (IL)1-receptor 1 and significantly more likely for carriers of the minor allele of a single nucleotide polymorphism in IL13.

"Findings suggest that breast pain occurs in over a quarter of women who are about to undergo breast cancer surgery," the authors write. "Based on phenotypic and genotypic characteristics found, inflammatory mechanisms contribute to preoperative breast pain."

Full Text (subscription or payment may be required)

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs