Younger Age, Taxane-Based Chemotherapy, Musculoskeletal Symptoms Predictive for Discontinuation of Aromatase Inhibitor Therapy

Share this content:

(ChemotherapyAdvisor) – Musculoskeletal symptoms were a specific cause of discontinuation of aromatase inhibitors (AIs) in nearly one-quarter of patients, with younger age and taxane-based chemotherapy associated with a higher likelihood of treatment discontinuation, a study of 503 women with early-stage breast cancer who had initiated AIs reported in the Journal of Clinical Oncology published online February 13.

The patients, enrolled in a multicenter, prospective, open-label randomized trial of exemestane vs letrozole, completed symptom questionnaires at baseline and during therapy. Those with intolerable symptoms who discontinued their AI could opt to switch to the other AI after a 2- to 8-week washout.

Within 2 years, 32.4% discontinued their initial AI due to adverse effects, 24.3% because of musculoskeletal symptoms. Median time to treatment discontinuation as a result of any symptom was 6.1 months and was significantly shorter in patients randomly assigned to exemestane (HR=1.5). Younger age (HR=1.4) and taxane-based chemotherapy (HR=1.9) were associated with higher likelihood of treatment discontinuation. Of 83 patients who switched to the second AI, 38.6% continued treatment for a median of 13.7 months.

Abstract

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs