Chemotherapy

Risk Score Identifies Adjuvant Chemotherapy Toxicity Risk in Elderly Patients With Breast Cancer

Risk Score Identifies Adjuvant Chemotherapy Toxicity Risk in Elderly Patients With Breast Cancer

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CARB-BC predicted grade 3 to 5 adverse events, dose modifications, and hospitalizations.

High CTC Count Favors Chemotherapy in First-Line ER+, HER2- Metastatic Breast Cancer

High CTC Count Favors Chemotherapy in First-Line ER+, HER2- Metastatic Breast Cancer

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CTC count may help guide the decision between first-line chemotherapy or endocrine therapy in ER-positive, HER-negative metastatic breast cancer.

Study Identifies Patients With Breast Cancer Who Don't Benefit From Adjuvant Chemo

Study Identifies Patients With Breast Cancer Who Don't Benefit From Adjuvant Chemo

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A meta-analysis showed that breast cancer patients who have a pathologic complete response after neoadjuvant chemotherapy may not benefit from adjuvant chemotherapy.

Gender-Based Differences in Chemotherapy: Efficacy and Safety

Gender-Based Differences in Chemotherapy: Efficacy and Safety

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Women and men were found to react differently to treatment with chemotherapy, although gender-based survival differences were not observed.

Cancer Chemotherapeutics in Rheumatoid Arthritis: A Complex Connection

Cancer Chemotherapeutics in Rheumatoid Arthritis: A Complex Connection

Research is still needed to explore the association between cancer chemotherapeutics and rheumatoid arthritis.

Care Coordination Recognized as Biggest Safety Concern in Oncology: Study

Care Coordination Recognized as Biggest Safety Concern in Oncology: Study

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In a recent analysis of VA hospital records, more than half of all oncologic errors and adverse events were attributed to uncoordinated cancer care.

Neoadjuvant Chemotherapy May Confer Benefit in Pancreatic Adenocarcinoma

Neoadjuvant Chemotherapy May Confer Benefit in Pancreatic Adenocarcinoma

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The addition of preoperative chemotherapy may eradicate micrometastatic disease and direct postoperative therapy in the case of resistance.

Uterine Re-Curettage May Not Affect Required Chemotherapy Courses in GTN

Uterine Re-Curettage May Not Affect Required Chemotherapy Courses in GTN

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After the initial year of follow-up, 2 patients in the standard arm and 1 patient in the re-curettage arm had relapsed.

Mapping Chemotherapy Checking Procedures May Improve Safety

Mapping Chemotherapy Checking Procedures May Improve Safety

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While checks were documented thoroughly in 3 centers, there were no internal standards for physician checks.

Metronomic Chemotherapy May Improve Outcomes Among Elderly Patients With HER2-Positive Breast Cancer

Metronomic Chemotherapy May Improve Outcomes Among Elderly Patients With HER2-Positive Breast Cancer

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Researchers evaluated whether dual HER2 inhibition with trastuzumab and pertuzumab plus metronomic cyclophosphamide is superior to dual HER2 inhibition alone.

FDA Grants Breakthrough Therapy Designation to DS-8201 for HER2+ Breast Cancer

FDA Grants Breakthrough Therapy Designation to DS-8201 for HER2+ Breast Cancer

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DS-8201 is an investigational HER2-targeting ADC, a targeted therapy for cancer that delivers cytotoxic chemotherapy by means of a linker on the monoclonal antibody that attaches to a specific target on cancer cells.

BRCA 1/2 Status in Triple-negative Breast Cancer May Affect Responsiveness to Carboplatin

BRCA 1/2 Status in Triple-negative Breast Cancer May Affect Responsiveness to Carboplatin

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Patients with triple-negative breast cancer without BRCA1 and BRCA2 germline mutations may benefit from the addition of carboplatin to a chemotherapy regimen.

Evofosfamide Not Recommended in First-line Sarcoma Treatment

Evofosfamide Not Recommended in First-line Sarcoma Treatment

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Adding evofosfamide to doxorubicin is not recommended as a first-line treatment for patients with advanced soft-tissue sarcoma.

Once-daily Radiotherapy Not Superior to Twice-daily in SCLC

Once-daily Radiotherapy Not Superior to Twice-daily in SCLC

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Once-daily radiotherapy is not superior to twice-daily treatment for patients with small-cell lung cancer receiving concurrent chemoradiotherapy.

HPV, p16 Status May Affect Prognosis in HNSCC

HPV, p16 Status May Affect Prognosis in HNSCC

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Among patients suffering post-radiation or chemoradiation locoregional HNSCC recurrence, those with HPV-positive disease may have better survival rates.

Histotype-guided Treatment Fails To Improve Outcomes in Sarcoma

Histotype-guided Treatment Fails To Improve Outcomes in Sarcoma

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A standard chemotherapy regimen was more efficacious than histotype-guided chemotherapy among patients with high-risk, localized sarcoma of the extremities or trunk wall.

Chemotherapy- and Radiation-Induced Nausea and Vomiting:  An Overview

Chemotherapy- and Radiation-Induced Nausea and Vomiting: An Overview

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A review of treatment options for patients experiencing chemotherapy- cr radiation-induced nausea and vomiting.

Chemotherapy-Induced and Radiotherapy-Induced Oral Mucositis

Chemotherapy-Induced and Radiotherapy-Induced Oral Mucositis

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Many patients who receive chemotherapy or radiotherapy as a part of their treatment for cancer develop oral mucositis, which is a painful, debilitating condition.

Clinician Communication, Perceived Burden Critical for Adherence to Oral Chemotherapy

Clinician Communication, Perceived Burden Critical for Adherence to Oral Chemotherapy

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Patients who reported better clinician communication or an improved satisfaction with their treatment were more likely to be adherent.

No Difference in Aprepitant vs Fosaprepitant in CINV

No Difference in Aprepitant vs Fosaprepitant in CINV

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This study indicates that there is no difference in efficacy or safety between aprepitant and fosaprepitant, though the study was limited by its small sample size.

Docetaxel-based Perioperative Therapy Recommended in Gastric Cancer

Docetaxel-based Perioperative Therapy Recommended in Gastric Cancer

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Study authors conclude that FLOT should be an internationally standard option for patients with resectable gastric cancer.

Adding Ramucirumab Does Not Improve PFS in Gastrointestinal Adenocarcinoma

Adding Ramucirumab Does Not Improve PFS in Gastrointestinal Adenocarcinoma

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Adding ramucirumab to mFOLFOX6 therapy in an intent-to-treat population of patients with GEJ does not improve PFS.

Antipsychotic Drug Olanzapine Prevents Nausea for Patients Receiving Chemotherapy

Antipsychotic Drug Olanzapine Prevents Nausea for Patients Receiving Chemotherapy

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Dopamine antagonist olanzapine prevents nausea and the complete response rate among previously untreated patients receiving highly emetogenic chemotherapy.

TAS-102 Ineffective for Treatment of Small Cell Lung Cancer

TAS-102 Ineffective for Treatment of Small Cell Lung Cancer

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TAS-102 improved survival, when contrasted with placebo, for patients with refractory colorectal cancer, though the drug showed no activity for the second-line treatment of patients with small cell lung cancer.

Neratinib May Be Efficacious for Treatment of HER2-Positive Breast Cancer

Neratinib May Be Efficacious for Treatment of HER2-Positive Breast Cancer

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Neratinib demonstrated clinical efficacy for patients with HER2-positive, hormone-receptor-negative breast cancer, in a phase 2 study.

Males With Recurrent Breast Cancer at Greater Risk of Mortality Than Females

Males With Recurrent Breast Cancer at Greater Risk of Mortality Than Females

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Males with breast cancer are less likely to survive than females after disease recurrence, which may be due to less aggressive treatment after relapse.

Myeloma: Carfilzomib Superior to Bortezomib Regardless of Number of Prior Treatments

Myeloma: Carfilzomib Superior to Bortezomib Regardless of Number of Prior Treatments

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Carfilzomib is superior to bortezomib for progression-free survival, regardless of previous treatments or prior exposure to either bortezomib or lenalidomide, for patients with multiple myeloma.

New Drug Combination May Be Beneficial for Newly-diagnosed Myeloma Patients

New Drug Combination May Be Beneficial for Newly-diagnosed Myeloma Patients

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The combination of ixazomib, cyclophosphamide, and dexamethasone induced high response rates with good tolerability in patients with newly-diagnosed multiple myeloma.

Adjuvant Chemo With S-1 Effective for Resected Pancreatic Cancer in Japanese Patients

Adjuvant Chemo With S-1 Effective for Resected Pancreatic Cancer in Japanese Patients

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Adjuvant chemotherapy with S-1 may improve standard of care for Japanese patients with resected pancreatic cancer.

Adding Olaratumab to Doxorubicin Improves Survival in Soft-tissue Sarcoma

Adding Olaratumab to Doxorubicin Improves Survival in Soft-tissue Sarcoma

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Addition of olaratumab to doxorubicin significantly improves PFS and OS in patients with advanced soft-tissue sarcoma.

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