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Cilostazol
Intermittent claudication
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Drug Name:

Cilostazol Rx

Generic Name and Formulations:
Cilostazol 50mg, 100mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Cilostazol:

Intermittent claudication.

Adult:

100mg twice daily, ½ hr before or 2 hrs after breakfast and dinner. May reduce to 50mg twice daily if used with CYP3A4 or CYP2C19 inhibitors.

Children:

Not established.

Contraindications:

Heart failure of any severity.

Boxed Warning:

Contraindicated in heart failure patients.

Warnings/Precautions:

Risk of tachycardia, palpitation, tachyarrhythmia, or hypotension. Risk of exacerbations of angina pectoris or MI in patients with history of ischemic heart disease. LV outflow tract obstruction: monitor for development of a new systolic murmur or cardiac symptoms. Monitor platelets and WBC periodically. Avoid use in hemostatic disorders or active pathologic bleeding. Moderate-to-severe hepatic impairment. Severe renal impairment. Dialysis. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Phosphodiesterase 3 (PDE3) inhibitor.

Interactions:

Potentiated by drugs that inhibit CYP3A4 (eg, azole antifungals, macrolides, diltiazem, protease inhibitors) or CYP2C19 (eg, omeprazole, fluconazole, fluoxetine, ticlopidine). Avoid grapefruit juice. Cilostazol has been used with aspirin; caution with other antiplatelets, anticoagulants.

Adverse Reactions:

Headache, diarrhea, abnormal stools, palpitations, peripheral edema, dizziness, pharyngitis, infection, tachycardia; rare: thrombocytopenia, leukopenia.

How Supplied:

Tabs—60

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