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Clomiphene
Infertility
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Drug Name:

Clomiphene Rx

Generic Name and Formulations:
Clomiphene citrate 50mg; scored tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Clomiphene:

Induction of ovulation.

Adult:

50mg daily for 5 days beginning on the 5th day of menstrual cycle; max 3 courses. If ovulation does not occur after 1st course, increase dose to 100mg daily for 2nd course; max 100mg/day for 5 days. See full labeling.

Children:

Not applicable.

Contraindications:

Primary ovarian failure. Ovarian cysts. Uterine leiomyomas. Abnormal uterine bleeding. Thrombophlebitis. Liver disease. Depression. Uncontrolled thyroid or adrenal dysfunction. Intracranial lesions. Pregnancy (Cat.X).

Warnings/Precautions:

Perform initial complete pelvic and endocrinologic exam. If ovarian enlargement occurs, hold dose until ovaries return to pretreatment size, and reduce dosage or duration of next course. Polycystic ovary syndrome. Discontinue if visual disorders occur. Metabolism disorders (eg, hypertriglyceridemia). Preexisting or family history of hyperlipidemia: monitor plasma triglycerides periodically. Nursing mothers.

Pharmacological Class:

Ovulatory stimulant.

Adverse Reactions:

Ovarian enlargement, vasomotor flushes, abdominal/pelvic discomfort/distention/bloating, nausea, vomiting, breast discomfort, visual symptoms (eg, blurred vision, lights, floaters), headache, abnormal uterine bleeding; multiple births, pancreatitis.

Note:

Formerly known under the brand name Serophene.

How Supplied:

Contact supplier.

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