Colon Cancer

Research Suggests 6-Month Adjuvant Chemotherapy May Be Superior to 3-Months in Stage III Colon Cancer, Particularly in T4 and/or N2 Subgroups

Research Suggests 6-Month Adjuvant Chemotherapy May Be Superior to 3-Months in Stage III Colon Cancer, Particularly in T4 and/or N2 Subgroups

By

Evidence from previous studies have shown that the legacy standard of 12-month fluoropyrimidine-based therapy could be reduced to 6 months, and perhaps even further to 3 months.

Phase 3 Trial of Regorafenib as Adjuvant Therapy in Colon Cancer

Phase 3 Trial of Regorafenib as Adjuvant Therapy in Colon Cancer

By

Researchers are investigating the efficacy of regorafenib in prolonging DFS among patients with stage IIIB or IIIC colon cancer compared with placebo.

Weight in Adolescence May Predict Colorectal Cancer Risk

Weight in Adolescence May Predict Colorectal Cancer Risk

By

Researchers evaluated BMI data from 1,087,358 men and 707,212 women in Israel to determine any link between weight in adolescence and colon/rectal cancer incidence.

Chemotherapy May Be Overused in Younger Patients With Colon Cancer

Chemotherapy May Be Overused in Younger Patients With Colon Cancer

Young and middle-aged colon cancer patients may be getting chemotherapy more often than is warranted.

Adjuvant Chemotherapy Fails To Prolong Survival Among Young Patients With Colon Cancer

Adjuvant Chemotherapy Fails To Prolong Survival Among Young Patients With Colon Cancer

By

The addition of chemotherapy after surgery did not provide a survival benefit among patients with young-onset colon cancer.

Location of Primary Tumor Is Important Prognostic Factor in Colon Cancer

Location of Primary Tumor Is Important Prognostic Factor in Colon Cancer

By

Whether the primary tumor is left- or right-sided should be considered when adjusting for treatment among patients with colon cancer.

Polycystic Kidney Disease Correlated With Risk of Cancer

Polycystic Kidney Disease Correlated With Risk of Cancer

By

Polycystic kidney disease (PKD) may increase one's risk of developing cancer of the liver, colon, and kidney.

Circulating Tumor DNA May Accurately Predict Recurrence of Colon Cancer

Circulating Tumor DNA May Accurately Predict Recurrence of Colon Cancer

By

A well-timed, sensitive liquid biopsy could effectively predict post-surgical recurrence of stage 2 colon cancer.

High Immunoscore Associated With Prolonged Time to Recurrence in Colon Cancer

High Immunoscore Associated With Prolonged Time to Recurrence in Colon Cancer

By

In patients with stage I, II, or III colon cancer, high Immunoscore was associated with significantly longer time to recurrence.

WNT/beta-catenin  Pathway Signaling Activated in Most Solid Tumors

WNT/beta-catenin Pathway Signaling Activated in Most Solid Tumors

WNT/β-catenin pathway signaling is associated with T cell exclusion and is activated in most human solid tumors, including colon, kidney, and lung tumors.

Left-sided Primary Colorectal Tumor Associated With Longer Survival

Left-sided Primary Colorectal Tumor Associated With Longer Survival

By

Metastatic colorectal cancer with the primary tumor located on the left side of the colon is associated with longer survival.

FDA Approves First-ever Blood Test for Colon Cancer Screening, Despite Split Opinion

FDA Approves First-ever Blood Test for Colon Cancer Screening, Despite Split Opinion

By

Physicians and cancer organizations suggest more research is needed before the Epi proColon blood test becomes a standard screening approach.

Early Mortality More Prevalent With Advanced Age, Higher Performance Status in Colon Cancer

Early Mortality More Prevalent With Advanced Age, Higher Performance Status in Colon Cancer

By

Early mortality may be infrequent but more prevalent in patients with colon cancer in an advanced age.

KRAS, BRAF V600 Tied to Lower Survival in Microsatellite Stable Colon Cancer Tumors

KRAS, BRAF V600 Tied to Lower Survival in Microsatellite Stable Colon Cancer Tumors

By

Post-hoc analysis of the PETACC-8 trial tied KRAS and BRAF V600E mutations to shorter overall and disease-free survival in microsatellite stable (MSS) colon cancer.

CDX2 Identified as Prognostic Biomarker in Stage 2, 3 Colon Cancer

CDX2 Identified as Prognostic Biomarker in Stage 2, 3 Colon Cancer

By

Patients with stage 2 or 3 CDX2-negative colon cancer might benefit from adjuvant chemotherapy.

DPYD Variants May Predict Fluorouracil-related Adverse Events in Colon Cancer

DPYD Variants May Predict Fluorouracil-related Adverse Events in Colon Cancer

By

Increased incidence of grade 3 or higher fluorouracil adverse events were linked with dihydropyrimidine dehydrogenase gene DPYD variants.

CDX2-negative Colon Cancer May Need More Therapy Post-surgery

CDX2-negative Colon Cancer May Need More Therapy Post-surgery

Colon tumors that don't produce the protein CDX2 are more likely to recur following surgical removal in patients with stage II colon cancer.

Updated MOSAIC Results Support FOLFOX Use for Stage 3 Colon Cancer

Updated MOSAIC Results Support FOLFOX Use for Stage 3 Colon Cancer

By

Benefit of oxaliplatin-based adjuvant chemotherapy was confirmed at 10 years in patients with stage 2 to 3 colon cancer.

Adjuvant Chemo for Colon Cancer Should Be Initiated Within 8 Weeks of Surgery

Adjuvant Chemo for Colon Cancer Should Be Initiated Within 8 Weeks of Surgery

By

Adjuvant chemotherapy in patients with stage 3 colon cancer should be initiated within 8 weeks of surgery.

XELOX as Standard Adjuvant Treatment Option for Stage 3 Colon Cancer

XELOX as Standard Adjuvant Treatment Option for Stage 3 Colon Cancer

By

Adjuvant XELOX improved overall survival compared with bolus 5-FU/FA in patients with resected stage 3 colon cancer.

Higher Travel Burden, Non-private Insurance Linked With Less Likelihood for Adjuvant Chemo

Higher Travel Burden, Non-private Insurance Linked With Less Likelihood for Adjuvant Chemo

By

Increased travel burden is associated with a decreased likelihood of receiving adjuvant chemotherapy for treatment of colon cancer.

Higher Coffee Intake May Be Linked With Reduced Colon Cancer Recurrence, Death

Higher Coffee Intake May Be Linked With Reduced Colon Cancer Recurrence, Death

By

Higher coffee intake may be associated with significantly reduced cancer recurrence and death in patients with stage 3 colon cancer.

Statin Use Linked with Lower Mortality after Colorectal Cancer Diagnosis

Statin Use Linked with Lower Mortality after Colorectal Cancer Diagnosis

By

Cumulative exposure to statins after a diagnosis of colorectal cancer was associated with lower overall mortality.

RMPs Prognostic Implications in Pts with Surgically Treated Colon Cancer

RMPs Prognostic Implications in Pts with Surgically Treated Colon Cancer

Radial margin positivity (RMP) associated with recurrence, risk of death, shorter survival in patients with colon cancer.

Possible Link Between rs61764370, Prognosis in Colorectal Cancer

Possible Link Between rs61764370, Prognosis in Colorectal Cancer

Single nucleotide polymorphism in the let-7 complementary site 6 of KRAS mRNA may be a response biomarker in colorectal cancer.

Colorectal Cancer Death "Hotspots" Indicate Need for Increased Screening in Some Areas

Colorectal Cancer Death "Hotspots" Indicate Need for Increased Screening in Some Areas

By

Investigators recommend prioritized screening in certain pockets of the U.S. that are statistically identified as colorectal cancer (CRC) death hotspots.

US State Disparities in Colorectal Cancer Rates

US State Disparities in Colorectal Cancer Rates

Greater progress in reducing colorectal cancer incidence, mortality rates observed in Northeastern states compared to Southern states.

Variant rs9929218 Linked with Prognosis of Patients with CRC

Variant rs9929218 Linked with Prognosis of Patients with CRC

Patients with colorectal cancer who have the variant rs9929218 at 16q22 are at an increased risk for worse survival.

Patients Receiving Surgical, Medical Oncology Care from Same Hospital May Improve Costs

Patients Receiving Surgical, Medical Oncology Care from Same Hospital May Improve Costs

By

Delivery of surgical and medical oncology care in patients with colon cancer at the same hospital was associated with lower costs.

Organoid Biobanks in Colon Cancer Show Promise in Personalized Treatment Options

Organoid Biobanks in Colon Cancer Show Promise in Personalized Treatment Options

By

Combining a previously established culture medium, researchers were able to create a colon tissue organoid, which could have implications for personalized treatment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs