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DEMADEX
Edema
Hypertension
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Drug Name:

DEMADEX Rx

Generic Name and Formulations:
Torsemide 5mg, 10mg, 20mg, 100mg; scored tabs.

Company:
Meda Pharmaceuticals

Therapeutic Use:

Indications for DEMADEX:

Edema.

Adult:

Edema due to CHF: 10–20mg once daily, if needed titrate upwards by doubling dose until desired response; max 200mg daily. Edema due to renal disease: 20mg once daily, if needed titrate upwards by doubling dose until desired response; max 200mg daily. Edema due to hepatic disease: 5–10mg once daily, give with aldosterone antagonist or potassium-sparing diuretic, may titrate upwards by doubling dose until desired response is achieved; max 40mg daily.

Children:

Not established.

Contraindications:

Anuria. Hepatic coma. Sulfonamide or povidone allergy.

Warnings/Precautions:

Hepatic disease with cirrhosis and ascites. New or worsening hepatic encephalopathy; consider suspending or discontinuing therapy. Renal impairment. Monitor electrolytes, blood glucose, renal function, and fluids. Pregnancy. Nursing mothers.

Pharmacological Class:

Diuretic (loop).

Interactions:

Lithium and salicylate toxicity. Caution with NSAIDs. Antagonized by organic anion drugs (eg, probenecid) and indomethacin. Give oral dose 1hr before or 4-6hrs after cholestyramine. Ototoxicity with aminoglycosides (avoid) and ethacrynic acid. Potentiated by concomitant CYP2C9 inhibitors (eg, amiodarone, fluconazole, miconazole, oxandrolone); monitor and adjust dose if needed. Antagonized by concomitant CYP2C9 inducers (eg, rifampin); monitor and adjust dose if needed. Concomitant CYP2C9 substrates and substrates with narrow therapeutic range (eg, celecoxib, warfarin, phenytoin); monitor and adjust dose if needed. Risk of hypotension and renal impairment with concomitant ACE inhibitors, ARBs, or nephrotoxic drugs (eg, aminoglycosides, cisplatin, NSAIDs). Increased nephrotoxicity with concomitant radiocontrast agents. Increased risk of hypokalemia with concomitant corticosteroids and ACTH.

Adverse Reactions:

Excessive urination; hypotension, renal dysfunction, electrolyte abnormalities, hyperglycemia, hyperuricemia, ototoxicity.

How Supplied:

Tabs—100


Data provided by MPR.

Indications for DEMADEX:

Hypertension.

Adult:

Initially 5mg once daily; may increase to 10mg daily after 4–6 weeks.

Children:

Not established.

Contraindications:

Anuria. Hepatic coma. Sulfonamide or povidone allergy.

Warnings/Precautions:

Hepatic disease with cirrhosis and ascites. New or worsening hepatic encephalopathy; consider suspending or discontinuing therapy. Renal impairment. Monitor electrolytes, blood glucose, renal function, and fluids. Pregnancy. Nursing mothers.

Pharmacological Class:

Diuretic (loop).

Interactions:

Lithium and salicylate toxicity. Caution with NSAIDs. Antagonized by organic anion drugs (eg, probenecid) and indomethacin. Give oral dose 1hr before or 4-6hrs after cholestyramine. Ototoxicity with aminoglycosides (avoid) and ethacrynic acid. Potentiated by concomitant CYP2C9 inhibitors (eg, amiodarone, fluconazole, miconazole, oxandrolone); monitor and adjust dose if needed. Antagonized by concomitant CYP2C9 inducers (eg, rifampin); monitor and adjust dose if needed. Concomitant CYP2C9 substrates and substrates with narrow therapeutic range (eg, celecoxib, warfarin, phenytoin); monitor and adjust dose if needed. Risk of hypotension and renal impairment with concomitant ACE inhibitors, ARBs, or nephrotoxic drugs (eg, aminoglycosides, cisplatin, NSAIDs). Increased nephrotoxicity with concomitant radiocontrast agents. Increased risk of hypokalemia with concomitant corticosteroids and ACTH.

Adverse Reactions:

Excessive urination; hypotension, renal dysfunction, electrolyte abnormalities, hyperglycemia, hyperuricemia, ototoxicity.

How Supplied:

Tabs—100


Data provided by MPR.

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