Doxycycline Monohydrate Tablets Rx
Generic Name and Formulations:
Doxycycline monohydrate 50mg, 100mg; tabs.
Indications for Doxycycline Monohydrate Tablets:
Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Postexposure prophylaxis and treatment of anthrax.
Usual dose: 200mg on first day (give as 100mg every 12hrs or 50mg every 6hrs) followed by maintenance dose of 100mg/day (may be given as a single dose or as 50mg every 12hrs). Management of severe infections (including chronic UTI): 100mg every 12hrs. Uncomplicated gonoccal infections (except anorectal infections in men): 100mg twice daily for 7 days or 300mg stat followed in one hour by a second 300mg dose. Acute epididymo-orchitis caused by N. gonorrhoeae, C. trachomatis: 100mg twice daily for at least 10 days. Primary and secondary syphilis: 300mg in divided doses for at least 10 days. Uncomplicated urethral, endocervical, or rectal infection caused by C. trachomatis, nongonococcal urethritis caused by C. trachomatis and U. urealyticum: 100mg twice daily for at least 7 days. Inhalational anthrax (post-exposure): 100mg twice daily for 60 days.
<8yrs: not recommended. >8yrs: ≤100lbs: 2mg/lb divided into two doses on the first day, followed by 1mg/lb as a single daily dose or divided into two doses, on subsequent days. Severe infections: up to 2mg/lb may be used. >100lbs: use adult dose. Inhalational anthrax (post-exposure): ≤100lbs: 1mg/lb twice daily for 60 days. >100lbs: use adult dose.
Monitor blood, renal, and liver function in long-term use. Avoid excessive sunlight or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.
Antacids, iron, zinc, calcium, magnesium reduce absorption. Avoid concomitant penicillin, methoxyflurane. Carbamazepine, phenytoin, barbiturates may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. May decrease effectiveness of oral contraceptives.
Photosensitivity, GI upset, esophageal irritation/ulceration (drink fluids liberally with dose), rash, increased BUN, hypersensitivity reactions, blood dyscrasias; pseudomembranous colitis.
Tabs 50mg—100; 100mg—50, 250
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- BRCA1/Shieldin Double Mutations May Signal Resistance to PARP Inhibitors
- Study Analyzing Postmarketing Data on Breast Implant Safety Sparks FDA Response
- Higher-Dose Immunoglobulin Replacement Therapy in Chronic Lymphocytic Leukemia
- Beyond BRCA: New Predisposition Genes Linked to Breast, Ovarian Cancers
- "Impressive" CNS Responses With Osimertinib Compared With Standard EGFR-TKIs in Patients With CNS Metastases at Baseline
- Despite Promising Trial Results, Skeptics Raise Red Flags About Anlotinib's Efficacy in Heavily Treated NSCLC
- Higher Risk of MGUS in Relatives of Patients With Multiple Myeloma Confirmed
- Brentuximab Vedotin Combo Active in Older Patients With Hodgkin Lymphoma
- Prostate Cancer Drug Resistance Mediated by Epigenetic Changes
- Nilotinib and Dasatinib Confer Similar Outcomes for Chronic-Phase CML