Miscellaneous hematological agents:
Indications for: ADAKVEO
To reduce the frequency of vaso-occlusive crises (VOCs) in sickle cell disease.
Adult Dosage:
Give by IV infusion over 30mins. ≥16yrs: 5mg/kg at Week 0, Week 2, and every 4 weeks thereafter.
Children Dosage:
<16yrs: not established.
ADAKVEO Warnings/Precautions:
Monitor for infusion-related reactions. Discontinue if severe infusion-related reactions occur; treat appropriately. Interrupt or slow infusion rate if mild to moderate infusion-related reactions occur; treat symptomatically. Consider premedication and/or reduced infusion rate for subsequent infusions. Pregnancy. Nursing mothers.
ADAKVEO Classification:
Selectin blocker.
ADAKVEO Interactions:
Caution with corticosteroids, unless indicated (eg, treating anaphylaxis). Interferes with automated platelet counts (esp. when collected in tubes containing EDTA) that may lead to unevaluable or falsely decreased platelet counts; run tests within 4hrs of collection or collect in citrate tubes instead.
Adverse Reactions:
Nausea, arthralgia, back pain, abdominal pain, pyrexia; infusion-related reactions.
Generic Drug Availability:
NO
How Supplied:
Single-dose vial (10mL)—1
