Miscellaneous hematological agents:

Indications for: ADAKVEO

To reduce the frequency of vaso-occlusive crises (VOCs) in sickle cell disease.

Adult Dosage:

Give by IV infusion over 30mins. ≥16yrs: 5mg/kg at Week 0, Week 2, and every 4 weeks thereafter.

Children Dosage:

<16yrs: not established.

ADAKVEO Warnings/Precautions:

Monitor for infusion-related reactions. Discontinue if severe infusion-related reactions occur; treat appropriately. Interrupt or slow infusion rate if mild to moderate infusion-related reactions occur; treat symptomatically. Consider premedication and/or reduced infusion rate for subsequent infusions. Pregnancy. Nursing mothers.

ADAKVEO Classification:

Selectin blocker.

ADAKVEO Interactions:

Caution with corticosteroids, unless indicated (eg, treating anaphylaxis). Interferes with automated platelet counts (esp. when collected in tubes containing EDTA) that may lead to unevaluable or falsely decreased platelet counts; run tests within 4hrs of collection or collect in citrate tubes instead.

Adverse Reactions:

Nausea, arthralgia, back pain, abdominal pain, pyrexia; infusion-related reactions.

Generic Drug Availability:


How Supplied:

Single-dose vial (10mL)—1