Indications for: ANCOBON
In combination with amphotericin B: Candida infections in septicemia, endocarditis, UTIs and pulmonary infections; cryptococcus infections in meningitis, pulmonary, septicemia, and UTIs.
Adults and Children:
Usually 50–150mg/kg per day given in divided doses every 6hrs. To minimize GI upset, give a few capsules at a time over 15mins. Renal impairment: give initial dose at lower range.
Known complete dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.
Use extreme caution in patients with impaired renal function.
Increased risk of severe drug toxicity in patients with DPD deficiency (see Contraindications). Consider discontinuing treatment if drug toxicity is suspected. Renal or hepatic impairment. Monitor electrolytes, blood count, renal and hepatic function before and during therapy. Bone marrow depression (eg, hematologic disease, history or currently treated with radiation or bone marrow depressants). Pregnancy. Nursing mothers: not recommended.
Antagonized by cytosine arabinoside. May be potentiated by drugs that impair glomerular filtration.
Cardiac events, chest pain, dyspnea, GI upset, abdominal pain, hepatic dysfunction, elevated creatinine and BUN, blood dyscrasias, ataxia, headache, confusion, fatigue, hypoglycemia, hypokalemia, rash, allergic reactions, others.
Generic Drug Availability: