Anxiety/OCD:
Indications for: Buspirone
Anxiety.
Adult Dosage:
Take consistently with regard to food. Initially 7.5mg twice daily, may increase by 5mg/day every 2–3 days. Usual range: 20–30mg/day; max 60mg/day.
Children Dosage:
<6yrs: not recommended. 6–17yrs: doses of 7.5–30mg twice daily have been used.
Buspirone Contraindications:
Concomitant MAOIs.
Buspirone Warnings/Precautions:
Severe renal or hepatic impairment: not recommended. Elderly. Labor & delivery. Pregnancy (Cat.B). Nursing mothers: not recommended.
Buspirone Classification:
Azaspirone.
Buspirone Interactions:
Hypertensive crisis with MAOIs: see Contraindications. Avoid alcohol, large amounts of grapefruit juice. Caution with other CNS drugs. May potentiate haloperidol, diazepam, nefazodone. Potentiated by nefazodone, verapamil, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir, other CYP3A4 inhibitors (use lower initial dose). Antagonized by rifampin, dexamethasone, phenytoin, phenobarbital, carbamazepine, other CYP3A4 inducers.
Adverse Reactions:
Dizziness, GI upset, headache, nervousness, CNS or emotional effects, nonspecific chest pain, tinnitus, dream disturbances.
How Supplied:
Contact supplier.
