Migraine and headache:

Indications for: Butalbital/Acetaminophen/Caffeine

Tension (or muscle contraction) headache.

Adult Dosage:

1–2 tabs or caps every 4hrs as needed; max 6 daily. Not recommended for extended or repeated use.

Children Dosage:

<12yrs: not established.

Butalbital/Acetaminophen/Caffeine Contraindications:


Boxed Warning:


Butalbital/Acetaminophen/Caffeine Warnings/Precautions:

Increased risk of acute liver failure esp. in those with underlying liver disease and concomitant alcohol. Discontinue at the 1st sign of skin rash or any other hypersensitivity. Drug abusers. Severe hepatic or renal impairment (monitor). Acute abdominal conditions.  Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended.

Butalbital/Acetaminophen/Caffeine Classification:

Barbiturate + analgesic + methylxanthine.

Butalbital/Acetaminophen/Caffeine Interactions:

May potentiate effects of alcohol, general anesthetics, tranquilizers, sedative-hypnotics, or other CNS depressants or narcotic analgesics; avoid. MAOIs may enhance CNS effects of butalbital. May cause false (+) urine test for 5-hydroxyindoleacetic acid.

Adverse Reactions:

Drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, abdominal pain, intoxicated feeling; hepatotoxicity (APAP doses >4g/day); rare: serious skin reactions (eg, acute generalized exanthematous pustulosis [AGEP], Stevens-Johnson Syndrome [SJS], toxic epidermal necrolysis [TEN]), hypersensitivity.


Formerly known under the brand name Esgic or Fioricet.

How Supplied:

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