Respiratory stimulants:

Indications for: CAFCIT INJECTION

Short-term treatment of apnea of prematurity in infants 28 to <33 weeks gestational age.

Adult Dosage:

Not applicable.

Children Dosage:

Use a syringe infusion pump when infusing. Loading dose: 20mg/kg caffeine citrate by IV infusion once (over 30 minutes); then, beginning 24 hours after loading dose: maintenance 5mg/kg caffeine citrate by IV infusion every 24 hours (over 10 minutes). Adjust based on response and serum caffeine levels.

CAFCIT INJECTION Warnings/Precautions:

Measure baseline serum caffeine levels in infants previously treated with theophylline (or aminophylline) and in infants born to mothers who consumed caffeine prior to delivery. Serious toxicity may occur with serum caffeine levels >50mg/L. Exclude or treat other causes of apnea. Seizure disorders. Cardiovascular disease. Monitor caffeine levels in impaired renal or hepatic function; adjust dose to avoid toxicity. Monitor serum glucose levels and for necrotizing enterocolitis. Pregnancy (Cat.C).

See Also:

CAFCIT INJECTION Classification:

Xanthine.

CAFCIT INJECTION Interactions:

Avoid concomitant theophylline, aminophylline (increased toxicity). May be potentiated by cimetidine, ketoconazole, others (may need to reduce caffeine dose). May be antagonized by phenobarbital, phenytoin, others (may need to increase caffeine dose). Caution with CYP1A2 substrates, inhibitors, or inducers.

Adverse Reactions:

CNS stimulation, cardiovascular or GI effects, increased gastric aspirate, feeding intolerance, hypo- or hyperglycemia, hemorrhage, acidosis, sepsis, lung edema, dyspnea, renal effects (eg, diuresis, renal failure), necrotizing enterocolitis.

Metabolism:

Hepatic (CYP1A2).

Drug Elimination:

Renal. Half-life: ~3–4 days (in neonates); 5hrs (in 9 months of age).

How Supplied:

Single-use vial (3mL)—1; Oral soln (3mL)—10