Select therapeutic use:

Angina:

Indications for: CARDIZEM CD

Vasospastic and chronic stable angina.

Clinical Trials:

Angina

  • The efficacy of Cardizem CD at doses from 60 to 480 mg once daily was evaluated in a double-blind, parallel, dose-response study.

    • Results showed that Cardizem CD increased time to termination of exercise in a linear manner over the entire dose range studied.

    • The improvement in time to termination of exercise utilizing a Bruce exercise protocol, measured at trough, for placebo, 60 mg, 120 mg, 240 mg, 360 mg, and 480 mg was 29, 40, 56, 51, 69, and 68 seconds, respectively. As doses of Cardizem CD were increased, overall angina frequency was decreased.  

  • In a double-blind study, Cardizem CD 180 mg once daily was compared to placebo in patients who were taking long-acting nitrates and/or beta-blockers.

    • Results showed a significant increase in time to termination of exercise and a significant decrease in overall angina frequency.

Adult Dosage:

Initially 120–180mg once daily. Titrate over 7–14 days; usual max 480mg once daily. Concomitant simvastatin: max 240mg/day.

Children Dosage:

Not established.

CARDIZEM CD Contraindications:

Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

CARDIZEM CD Warnings/Precautions:

CHF. Renal or hepatic impairment (monitor). Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

See Also:

CARDIZEM CD Classification:

Calcium channel blocker (CCB) (benzothiazepine).

CARDIZEM CD Interactions:

Concomitant ivabradine, rifampin, alcohol: avoid. Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, quinidine, lovastatin, simvastatin (limit to max 10mg/day); monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers. Anesthetics may potentiate cardiac depression.

Adverse Reactions:

Edema, headache, fatigue, dizziness, asthenia, 1st-degree AV block, bradycardia, rash (may be serious); rare: hypotension, liver abnormalities.

Metabolism:

Hepatic.

Drug Elimination:

Renal. Half-life: 5–8hrs.

How Supplied:

LA tabs—30, 90; CD 120mg, 180mg, 240mg, 300mg—30, 90; CD 360mg—90; Tabs 30mg—100, 500; 60mg, 90mg, 120mg—100

Hypertension:

Indications for: CARDIZEM CD

Hypertension.

Clinical Trials:

Hypertension

  • The efficacy of Cardizem CD at doses ranging from 90 to 540 mg once daily was evaluated in a double-blind, parallel, dose-response study. 

    • Results showed that Cardizem CD lowered supine diastolic blood pressure in an apparent linear manner over the entire dose range studied.

    • The changes in diastolic blood pressure, measured at trough, for placebo, 90 mg, 180 mg, 360 mg, and 540 mg were –2.9, –4.5, –6.1, –9.5, and –10.5 mmHg, respectively.

    • Patients who received Cardizem CD had decreased vascular resistance, increased cardiac output (due to increased stroke volume), and a slight decrease or no change in heart rate. Cardizem CD also reduced the renal and peripheral effects of angiotensin II.

Adult Dosage:

Initially 180–240mg once daily; adjust at 2-week intervals. Usual range: 240–360mg once daily; usual max 480mg once daily. Concomitant simvastatin: max 240mg/day.

Children Dosage:

Not established.

CARDIZEM CD Contraindications:

Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

CARDIZEM CD Warnings/Precautions:

CHF. Renal or hepatic impairment (monitor). Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

See Also:

CARDIZEM CD Classification:

Calcium channel blocker (CCB) (benzothiazepine).

CARDIZEM CD Interactions:

Concomitant ivabradine, rifampin, alcohol: avoid. Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, quinidine, lovastatin, simvastatin (limit to max 10mg/day); monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers. Anesthetics may potentiate cardiac depression.

Adverse Reactions:

Edema, headache, fatigue, dizziness, asthenia, 1st-degree AV block, bradycardia, rash (may be serious); rare: hypotension, liver abnormalities.

Metabolism:

Hepatic.

Drug Elimination:

Renal. Half-life: 6–9hrs.

How Supplied:

LA tabs—30, 90; CD 120mg, 180mg, 240mg, 300mg—30, 90; CD 360mg—90