- Breast cancer
- CNS cancers
- Eye cancer
- Gynecologic Cancers
- Leukemias, lymphomas, and other hematologic cancers
Breast cancer:
Indications for: Cyclophosphamide
Carcinoma of the breast.
Adult Dosage:
Initial and maintenance: 1–5mg/kg/day.
Children Dosage:
See full labeling.
Cyclophosphamide Contraindications:
Severe bone marrow depression.
Cyclophosphamide Warnings/Precautions:
Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.
See Also:
Cyclophosphamide Classification:
Alkylating agent.
Cyclophosphamide Interactions:
Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.
Adverse Reactions:
GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.
Note:
Formerly known under the brand name Cytoxan.
How Supplied:
Contact supplier
CNS cancers:
Indications for: Cyclophosphamide
Neuroblastoma (disseminated disease).
Adult Dosage:
Initial and maintenance: 1–5mg/kg/day.
Children Dosage:
See full labeling.
Cyclophosphamide Contraindications:
Severe bone marrow depression.
Cyclophosphamide Warnings/Precautions:
Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.
See Also:
Cyclophosphamide Classification:
Alkylating agent.
Cyclophosphamide Interactions:
Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.
Adverse Reactions:
GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.
Note:
Formerly known under the brand name Cytoxan.
How Supplied:
Contact supplier
Eye cancer:
Indications for: Cyclophosphamide
Retinoblastoma.
Adult Dosage:
Initial and maintenance: 1–5mg/kg/day.
Children Dosage:
See full labeling.
Cyclophosphamide Contraindications:
Severe bone marrow depression.
Cyclophosphamide Warnings/Precautions:
Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.
See Also:
Cyclophosphamide Classification:
Alkylating agent.
Cyclophosphamide Interactions:
Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.
Adverse Reactions:
GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.
Note:
Formerly known under the brand name Cytoxan.
How Supplied:
Contact supplier
Gynecologic Cancers:
Leukemias, lymphomas, and other hematologic cancers:
Indications for: Cyclophosphamide
Malignant lymphomas (Stages III and IV of the Ann Arbor staging system), Hodgkin's disease, lymphocytic lymphoma (nodular or diffuse), mixed-cell type lymphoma, histiocytic lymphoma, Burkitt's lymphoma. Multiple myeloma. Leukemias: chronic lymphocytic leukemia, chronic granulocytic leukemia (it is usually ineffective in acute blastic crisis), acute myelogenous and monocytic leukemia, acute lymphoblastic (stem-cell) leukemia in children (cyclophosphamide given during remission is effective in prolonging its duration). Mycosis fungoides (advanced disease).
Adult Dosage:
Initial and maintenance: 1–5mg/kg/day.
Children Dosage:
See full labeling.
Cyclophosphamide Contraindications:
Severe bone marrow depression.
Cyclophosphamide Warnings/Precautions:
Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.
See Also:
Cyclophosphamide Classification:
Alkylating agent.
Cyclophosphamide Interactions:
Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.
Adverse Reactions:
GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.
Note:
Formerly known under the brand name Cytoxan.
How Supplied:
Contact supplier
