Indications for Demeclocycline HCl:
Tetracycline-sensitive infections, including respiratory, genitourinary, skin and skin structure, soft tissues, and those caused by rickettsiae and Mycoplasma pneumoniae; also cholera, psittacosis, plague, shigellosis.
Take with fluids, 1hr before or 2hrs after meals. 150mg 4 times daily or 300mg twice daily. Gonorrhea patients sensitive to penicillin: initially 600mg followed by 300mg every 12hrs for 4 days to a total of 3g.
<8yrs: not recommended. Take with fluids, 1hr before or 2hrs after meals. ≥8yrs: 7–13mg/kg/day divided into 2–4 doses; max 600mg/day.
Renal or hepatic impairment. Monitor blood, renal and hepatic function in long-term use. Avoid sun and UV light. Discontinue if skin erythema occurs. Pregnancy (Cat.D), nursing mothers: not recommended.
Avoid methoxyflurane, photosensitizing agents. May antagonize bactericidal antibiotics; avoid. Reduced absorption with antacids, iron, zinc, calcium, magnesium, dairy products, urinary alkalinizers, other multivalent cations. May reduce effectiveness of oral contraceptives. Monitor prothrombin time with oral anticoagulants.
Photosensitivity, GI upset, rash, blood dyscrasias, increased BUN, hepatotoxicity, C. difficile associated diarrhea, pseudotumor cerebri; rare: esophagitis and esophageal ulceration.
Formerly known under the brand name Declomycin.