Overactive bladder/enuresis:
Indications for: DETROL
Overactive bladder with symptoms of urinary frequency, urgency, or urge incontinence.
Adult Dosage:
2mg twice daily; may decrease to 1mg twice daily. Concomitant strong CYP3A4 inhibitors (ketoconazole, itraconazole, miconazole, clarithromycin, erythromycin, cyclosporine, vinblastine), or significant renal or hepatic dysfunction: 1mg twice daily.
Children Dosage:
Not established.
DETROL Contraindications:
Urinary or gastric retention. Uncontrolled narrow-angle glaucoma. Fesoterodine fumarate allergy.
DETROL Warnings/Precautions:
Bladder outflow obstruction. GI obstruction (eg, pyloric stenosis). Decreased GI motility. Discontinue if angioedema occurs. Monitor for anticholinergic CNS effects (esp. when starting treatment and after dose increases). Narrow-angle glaucoma. Myasthenia gravis. History of QT prolongation. Pregnancy. Nursing mothers: not recommended.
See Also:
DETROL Classification:
Muscarinic antagonist.
DETROL Interactions:
Plasma levels increased by CYP3A4 inhibitors (see Adult dose). Caution with Class IA (eg, quinidine, procainamide) or Class III (eg, amiodarone, sotalol) antiarrhythmics. Additive anticholinergic effects with other anticholinergics.
Adverse Reactions:
Dry mouth/eyes, headache, constipation, abdominal pain, dyspepsia, fatigue, dizziness, somnolence, sinusitis, abnormal vision, anxiety, dysuria, other anticholinergic effects; anaphylaxis, angioedema.
Drug Elimination:
Renal (primarily), fecal.
Generic Drug Availability:
YES
How Supplied:
LA—30, 90, 500; Tabs—60, 500
