Addiction/dependence:
Indications for: Diazepam Injection
Acute alcohol withdrawal.
Adult Dosage:
Initially 10mg IM or IV, then 5–10mg in 3–4hrs as needed. Do not use small vein.
Children Dosage:
Not established.
Diazepam Injection Contraindications:
Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.
Boxed Warning:
Risks from concomitant use with opioids. Abuse, misuse, and addiction. Dependence and withdrawal reactions.
Diazepam Injection Warnings/Precautions:
Increased risk of drug-related mortality from concomitant use with opioids. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Psychosis. May increase severity of seizures. Renal or hepatic impairment. Assess patient's risk for abuse, misuse, addiction prior to and during therapy. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Inj: not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Drug or alcohol abusers. Elderly. Debilitated. Labor & delivery. Neonatal sedation and withdrawal syndrome; monitor neonates exposed during pregnancy or labor. Pregnancy (esp. late stage). Nursing mothers: not recommended.
See Also:
Diazepam Injection Classification:
Benzodiazepine.
Diazepam Injection Interactions:
Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.
Adverse Reactions:
Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, local irritation, swelling, tonic status epilepticus (when treating petit mal), propylene glycol toxicity, withdrawal reactions.
How Supplied:
Tabs 2mg—100; Tabs 5mg, 10mg—100, 500; Vials (10mL)—contact supplier
Anxiety/OCD:
Indications for: Diazepam Injection
Anxiety.
Adult Dosage:
Moderate: 2–5mg. Severe: 5–10mg. Both deep IM or slow IV (5mg/min). May repeat in 3–4 hours. Do not use small vein.
Children Dosage:
Not recommended.
Diazepam Injection Contraindications:
Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.
Boxed Warning:
Risks from concomitant use with opioids. Abuse, misuse, and addiction. Dependence and withdrawal reactions.
Diazepam Injection Warnings/Precautions:
Increased risk of drug-related mortality from concomitant use with opioids. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Psychosis. May increase severity of seizures. Renal or hepatic impairment. Assess patient's risk for abuse, misuse, addiction prior to and during therapy. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Inj: not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Drug or alcohol abusers. Elderly. Debilitated. Labor & delivery. Neonatal sedation and withdrawal syndrome; monitor neonates exposed during pregnancy or labor. Pregnancy (esp. late stage). Nursing mothers: not recommended.
See Also:
Diazepam Injection Classification:
Benzodiazepine.
Diazepam Injection Interactions:
Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.
Adverse Reactions:
Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, local irritation, swelling, tonic status epilepticus (when treating petit mal), propylene glycol toxicity, withdrawal reactions.
Drug Elimination:
Renal. Terminal half-life: up to 100 hours (N-desmethyldiazepam).
How Supplied:
Tabs 2mg—100; Tabs 5mg, 10mg—100, 500; Vials (10mL)—contact supplier
Muscle spasms:
Indications for: Diazepam Injection
Skeletal muscle spasm.
Adult Dosage:
Initially 5–10mg slow IV (5mg/min) or IM. May repeat after 3–4hrs. Tetanus: may need larger dose. Do not use small vein.
Children Dosage:
Max 0.25mg/kg over 3 minutes; if no response after 3rd dose consider adjunctive therapy. Tetanus: age <30 days: not recommended. 30 days–5yrs: 1–2mg IM or slow IV. >5yrs: 5–10mg IM or slow IV. Both: may repeat after 3–4hrs. Do not use small vein.
Diazepam Injection Contraindications:
Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.
Boxed Warning:
Risks from concomitant use with opioids. Abuse, misuse, and addiction. Dependence and withdrawal reactions.
Diazepam Injection Warnings/Precautions:
Increased risk of drug-related mortality from concomitant use with opioids. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Psychosis. May increase severity of seizures. Renal or hepatic impairment. Assess patient's risk for abuse, misuse, addiction prior to and during therapy. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Inj: not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Drug or alcohol abusers. Elderly. Debilitated. Labor & delivery. Neonatal sedation and withdrawal syndrome; monitor neonates exposed during pregnancy or labor. Pregnancy (esp. late stage). Nursing mothers: not recommended.
See Also:
Diazepam Injection Classification:
Benzodiazepine.
Diazepam Injection Interactions:
Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.
Adverse Reactions:
Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, local irritation, swelling, tonic status epilepticus (when treating petit mal), propylene glycol toxicity, withdrawal reactions.
How Supplied:
Tabs 2mg—100; Tabs 5mg, 10mg—100, 500; Vials (10mL)—contact supplier
Seizure disorders:
Indications for: Diazepam Injection
Adjunct in status epilepticus and recurrent seizures.
Adult Dosage:
Initially 5–10mg slow IV (5mg/min). May repeat every 10–15 minutes; max 30mg. Repeat in 2–4 hours if needed. Do not dilute. May give IM if IV impossible. Do not use small vein.
Children Dosage:
Max 0.25mg/kg over 3 minutes; if no response after 3rd dose consider adjunctive therapy. Age <30 days: not recommended. 30 days–5yrs: 0.2–0.5mg slow IV every 2–5 minutes; max 5mg. >5yrs: 1mg slow IV every 2–5 minutes; max 10mg. Repeat in 2–4 hours if needed. Do not use small vein.
Diazepam Injection Contraindications:
Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.
Boxed Warning:
Risks from concomitant use with opioids. Abuse, misuse, and addiction. Dependence and withdrawal reactions.
Diazepam Injection Warnings/Precautions:
Increased risk of drug-related mortality from concomitant use with opioids. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Psychosis. May increase severity of seizures. Renal or hepatic impairment. Assess patient's risk for abuse, misuse, addiction prior to and during therapy. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Inj: not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Drug or alcohol abusers. Elderly. Debilitated. Labor & delivery. Neonatal sedation and withdrawal syndrome; monitor neonates exposed during pregnancy or labor. Pregnancy (esp. late stage). Nursing mothers: not recommended.
See Also:
Diazepam Injection Classification:
Benzodiazepine.
Diazepam Injection Interactions:
Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.
Adverse Reactions:
Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, local irritation, swelling, tonic status epilepticus (when treating petit mal), propylene glycol toxicity, withdrawal reactions.
Drug Elimination:
Renal. Terminal half-life: up to 100 hours (N-desmethyldiazepam).
How Supplied:
Tabs 2mg—100; Tabs 5mg, 10mg—100, 500; Vials (10mL)—contact supplier
