Arthritis/rheumatic disorders:

Indications for: DUROLANE

For the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacological therapy or simple analgesics (eg, acetaminophen).

Adult Dosage:

Remove joint effusion before inj. Give as a single intra-articular inj. 3mL per knee or hip. Local anesthetic by SC inj or topical freezing agents may be used prior to inj. Use separate syringes for each joint.

Children Dosage:

Not studied.

DUROLANE Contraindications:

Knee joint infections, infections, or skin disease in the area of injection site. 

DUROLANE Warnings/Precautions:

Do not inject by intravascular or extra-articular route, or in the synovial tissues or capsule. Avoid infected or severely inflamed synovial joint, active skin disease or infection at or near inj site. Venous or lymphatic stasis in the leg. Pre-existing chondrocalcinosis. Hyaluronic acid sensitivity. Avoid strenuous activity within 48hrs after injection. Pregnancy, nursing mothers: not studied.

DUROLANE Classification:


DUROLANE Interactions:

Concomitant other intra-articular injectables: not established.

Adverse Reactions:

Transient pain, swelling, joint stiffness; infection.

Generic Drug Availability:


How Supplied:

Single-use prefilled syringe (3mL)—1