Colorectal disorders:

Indications for: ENTEREG

To accelerate the time to upper and lower gastrointestinal recovery following surgeries that include partial bowel resection surgery with primary anastomosis.

Adult Dosage:

Give 12mg 30mins to 5hrs before surgery, then 12mg twice daily starting on 1st post-op day until hospital discharge for up to 7 days; max 15 doses.

Children Dosage:

Not established.

ENTEREG Contraindications:

Opioid use, at therapeutic doses, for >7 consecutive days prior.

Boxed Warning:

Potential risk of MI with long-term use: for short-term hospital use only.

ENTEREG Warnings/Precautions:

For short-term hospital use only. Potential risk of MI with long-term use. Severe hepatic impairment, ESRD, complete GI obstruction, pancreatic or gastric anastomosis: not recommended. Mild to severe renal impairment or mild to moderate hepatic impairment: monitor closely; discontinue if adverse reactions occur. Recent (within week prior to surgery) use of >3 doses of opioids; monitor for GI events. Japanese patients (monitor). Pregnancy. Nursing mothers.

ENTEREG Classification:

Opioid antagonist (peripheral).

Adverse Reactions:



Available only to hospitals that enroll in the Alvimopan REMS Program. For more information, and to enroll, call (800) 278-0340.



How Supplied: