Prostate and other male cancers:
Indications for ERLEADA:
Metastatic castration-sensitive prostate cancer. Non-metastatic, castration-resistant prostate cancer.
Adult:
Swallow whole (alternatively, may be mixed in applesauce if difficulty swallowing; see full labeling). Take with or without food. 240mg once daily. Give concurrent GnRH analog or patient should have had bilateral orchiectomy. Dose modification: see full labeling.
Children:
Not established.
Warnings/Precautions:
Monitor for signs/symptoms of ischemic heart disease; consider discontinuing if Grade 3/4 events occur. Manage CV risk factors (eg, hypertension, diabetes, dyslipidemia) optimally. Risk of seizures; permanently discontinue if occurs. Evaluate for fracture risk (monitor/manage based on guidelines; consider bone-targeted agents) and fall risk (esp. elderly). Embryo-fetal toxicity. Advise males (w. female partners of reproductive potential) to use effective contraception during and for 3 months after last dose.
Pharmacologic Class:
Androgen receptor inhibitor.
Interactions:
Potentiated by strong CYP2C8 or CYP3A4 inhibitors; reduce dose based on tolerability. Antagonizes drugs metabolized by CYP3A4, CYP2C19, or CYP2C9; use alternatives when possible. Caution with concomitant P-gp, BCRP, OATP1B1, or UGT substrates.
Adverse Reactions:
Fatigue, arthralgia, rash, decreased appetite, fall, weight decreased, hypertension, hot flush, diarrhea, fracture; ischemic CV events.
Generic Availability:
NO
How Supplied:
Tabs—120
