Leukemias, lymphomas, and other hematologic cancers:

Indications for: Fludarabine

B-cell chronic lymphocytic leukemia (CLL) in patients who have not responded to or whose disease progressed during treatment with at least 1 alkylating-agent containing regimen.

Adult Dosage:

Give by IV infusion over 30 minutes. 25mg/m2 daily for 5 days every 28 days. Renal dysfunction (CrCl 30–70mL/min): reduce dose by 20%; CrCl <30mL/min: not recommended. Give for 3 cycles after the max response. Reduce or delay dose if toxicity occurs.

Children Dosage:

Not recommended.

Boxed Warning:

Severe bone marrow suppression. CNS toxicity. Hemolytic anemia. Pulmonary toxicity.

Fludarabine Warnings/Precautions:

Myelosuppression. Evaluate and monitor for hemolysis. Monitor blood (esp CBC, platelets). Use irradiated blood products if transfusions are required. May need to prophylax for tumor lysis syndrome with large tumors. Renal insufficiency. Delay or stop therapy if neurotoxicity occurs. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Fludarabine Classification:

Antimetabolite.

Fludarabine Interactions:

Severe pulmonary toxicity with pentostatin (not recommended).

Adverse Reactions:

Myelosuppression (severe/cumulative), bone marrow hypoplasia, autoimmune hemolytic anemia (fatal/severe), infection, fever, chills, GI upset, malaise, fatigue, CNS effects (eg, weakness, agitation, confusion, visual disturbances, coma, peripheral neuropathy), pneumonia, pulmonary hypersensitivity (eg, dyspnea, interstitial pulmonary infiltrate), stomatitis, GI bleeding, edema, tumor lysis syndrome, rash, hemorrhagic cystitis (rare); others.

Note:

Formerly known under the brand name Fludara.

How Supplied:

Contact supplier

Pricing for Fludarabine

2ml of 50mg/2ml vial (Qty: 1)
Appx. price $49
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