Hypotension:
Indications for: GIAPREZA
To increase blood pressure in septic or other distributive shock.
Adult Dosage:
Give by IV infusion. Initially 20ng/kg/min. May titrate every 5mins by increments of up to 15ng/kg/min as needed based on BP response; max 80ng/kg/min during first 3hrs of treatment. Maintenance dose: max 40ng/kg/min. Doses as low as 1.25ng/kg/min may be used. Once sufficiently improved, down-titrate every 5–15mins by increments of up to 15ng/kg/min based on BP.
Children Dosage:
Not established.
GIAPREZA Warnings/Precautions:
Risk of thrombosis. Use concurrent VTE prophylaxis. Pregnancy. Nursing mothers.
GIAPREZA Classification:
Vasoconstrictor.
GIAPREZA Interactions:
Concomitant ACE inhibitors may increase response. Concomitant ARBs may decrease response.
Adverse Reactions:
Thromboembolic events (eg, deep vein thrombosis), thrombocytopenia, tachycardia, fungal infection, delirium, acidosis, hyperglycemia, peripheral ischemia.
Generic Drug Availability:
NO
How Supplied:
Single-dose vial (1mL, 2mL)—1
