Pricing for HYCAMTIN
Respiratory and thoracic cancers:
Indications for HYCAMTIN:
Small cell lung cancer (SCLC) with platinum-sensitive disease that progressed at least 60 days after initiation of 1st line chemotherapy.
Verify dose using BSA. Usual max dose 4mg IV. Confirm baseline neutrophils ≥1,500cells/mm3 and platelets ≥100,000cells/mm3 prior to 1st course of therapy. Give by IV infusion over 30mins. 1.5mg/m2 daily for 5 consecutive days, starting on Day 1 of a 21-day cycle. Renal impairment (CrCl 20–39mL/min): 0.75mg/m2/day. Dose modifications: see full labeling.
Monitor blood counts frequently during therapy; hold subsequent doses until neutrophils >1,000cells/mm3, platelets >100,000cells/mm3, and hemoglobin ≥9g/dL. History of interstitial lung disease (ILD), pulmonary fibrosis, lung cancer, thoracic radiation, use of pneumotoxic drugs and/or colony stimulating factors. Monitor for pulmonary symptoms indicative of ILD; permanently discontinue if ILD is confirmed. Moderate to severe renal impairment (see Adults). Caps: severe diarrhea; may need to reduce dose. IV: avoid extravasation. Embryo-fetal toxicity. Advise use of effective contraception during and for 6 months (females) or 3 months (males w. female partners) after the last dose. Pregnancy: exclude status prior to initiation. Nursing mothers: not recommended (during and for 1 week after the last dose).
IV: myelosuppression potentiated with platinum agents. Caps: potentiated by P-gp (eg, cyclosporine) or BCRP inhibitors; avoid concomitant use.
Neutropenia, anemia, thrombocytopenia, febrile neutropenia, nausea, vomiting, fatigue, diarrhea, dyspnea, asthenia, pneumonia, abdominal pain, pain, infection, alopecia, anorexia; ILD, neutropenic colitis (may be fatal).
Single-use vials—1; Caps—10